Title:
TC AND RE-LABELED RADIOACTIVE GLYCOSYLATED OCTREOTIDE DERIVATIVE
Document Type and Number:
Japanese Patent JP2010001313
Kind Code:
A
Abstract:
To provide a novel radioactive octreotide derivative which is glycosylated and binds to a somatostatin receptor.
An improved sst-receptor-binding peptidic ligand for diagnostic and therapeutic applications in nuclear medicine is provided. The improved ligand includes a natural or unnatural amino acid or peptidomimetic structure, a carbohydrate unit, and a chelator or a prosthetic group at either the N- or C-terminal or at both terminals to provide a complexation of a radioisotope binding or holding a radioisotope. The sst- or SSTR-receptor binding peptidic ligand may also contain one or more multifunctional linker units optionally coupling peptides, and/or a sugar moiety and/or chelator and/or prosthetic group.
Inventors:
WESTER HANS-JURGEN
SCHOTTELIUS MARGRET
SCHWAIGER MARKUS
SCHOTTELIUS MARGRET
SCHWAIGER MARKUS
Application Number:
JP2009228998A
Publication Date:
January 07, 2010
Filing Date:
September 30, 2009
Export Citation:
Assignee:
MALLINCKRODT INC
International Classes:
A61K51/00; A61K47/18; C07K7/06; A61K47/26; A61K47/42; A61K47/48; A61K51/08; A61P35/00; A61P43/00; C07B59/00; C07K2/00
Attorney, Agent or Firm:
Takeshi Oshio
Previous Patent: NAALADase INHIBITOR USEFUL AS PHARMACEUTICAL COMPOUND AND COMPOSITION
Next Patent: METHOD OF TREATING INFLAMMATION
Next Patent: METHOD OF TREATING INFLAMMATION