Title:
神経疾患を治療するためのテルペノイド類似体およびその使用
Document Type and Number:
Japanese Patent JP2013538218
Kind Code:
A
Abstract:
The present application provides a terpene analogue of Formula (I) or a pharmaceutically acceptable isomer, salt or ester thereof, and methods and uses thereof for treating neurological conditions such as pain in general and neuropathic pain. These terpene analogues can also be used to treat other electrical disorders in the central and peripheral nervous system. Also provided are methods of synthesizing the terpene analogues of Formula I.
Inventors:
Lead Mark A.
Weaver donald
San Sheng Guo
McClellan Alexander
Roux ahu
Weaver donald
San Sheng Guo
McClellan Alexander
Roux ahu
Application Number:
JP2013528482A
Publication Date:
October 10, 2013
Filing Date:
September 14, 2011
Export Citation:
Assignee:
Neuroquest Inc.
International Classes:
A61K31/08; A61K31/10; A61K31/11; A61K31/121; A61K31/131; A61K31/133; A61K31/137; A61K31/16; A61K31/166; A61K31/167; A61K31/18; A61K31/201; A61K31/41; A61P25/00; A61P25/04; A61P29/02
Domestic Patent References:
| JP2010518030A | 2010-05-27 | |||
| JPH07501555A | 1995-02-16 |
Foreign References:
| WO1993017695A1 | 1993-09-16 | |||
| WO2010057295A1 | 2010-05-27 |
Other References:
JPN6015030241; Ａｂｅｎａ ＡＡ， ｅｔ ａｌ．: Ａｆｒ． Ｊ． Ｔｒａｄ． ＣＡＭ Ｖｏｌ．４， Ｎｏ．２, 2007, ｐ．２６７-２７２
JPN6015030242; Ｏｒｔｉｚ ＭＩ， ｅｔ ａｌ．: Ａｒｃｈ Ｐｈａｒｍ Ｒｅｓ Ｖｏｌ．３３， Ｎｏ．１０, 2010, ｐ．１６９１-１６９７
JPN6015030245; Ｇｕｎｔｈｏｒｐｅ ＭＪ， ｅｔ ａｌ．: Ｄｒｕｇ Ｄｉｓｃｏｖｅｒｙ Ｔｏｄａｙ Ｖｏｌ．１４， Ｎｏ．１／２, 2009, ｐ．５６-６７
JPN6015030246; Ｓｔｏｔｚ ＳＣ， ｅｔ ａｌ．: ＰＬｏＳ ＯＮＥ Ｖｏｌ．３， Ｎｏ．５, 2008, ｐ．１-１４
JPN6015030248; Ｌａｉ Ｊ， ｅｔ ａｌ．: Ｃｕｒｒｅｎｔ Ｏｐｉｎｉｏｎ ｉｎ Ｎｅｕｒｏｂｉｏｌｏｇｙ Ｖｏｌ．１３, 2003, ｐ．２９１-２９７
JPN6015030242; Ｏｒｔｉｚ ＭＩ， ｅｔ ａｌ．: Ａｒｃｈ Ｐｈａｒｍ Ｒｅｓ Ｖｏｌ．３３， Ｎｏ．１０, 2010, ｐ．１６９１-１６９７
JPN6015030245; Ｇｕｎｔｈｏｒｐｅ ＭＪ， ｅｔ ａｌ．: Ｄｒｕｇ Ｄｉｓｃｏｖｅｒｙ Ｔｏｄａｙ Ｖｏｌ．１４， Ｎｏ．１／２, 2009, ｐ．５６-６７
JPN6015030246; Ｓｔｏｔｚ ＳＣ， ｅｔ ａｌ．: ＰＬｏＳ ＯＮＥ Ｖｏｌ．３， Ｎｏ．５, 2008, ｐ．１-１４
JPN6015030248; Ｌａｉ Ｊ， ｅｔ ａｌ．: Ｃｕｒｒｅｎｔ Ｏｐｉｎｉｏｎ ｉｎ Ｎｅｕｒｏｂｉｏｌｏｇｙ Ｖｏｌ．１３, 2003, ｐ．２９１-２９７
Attorney, Agent or Firm:
Koichi Washida