Title:
テトラヒドロ−ベンゾジアゼピノン類
Document Type and Number:
Japanese Patent JP6680683
Kind Code:
B2
Abstract:
Disclosed are compounds of Formula I, or pharmaceutically acceptable salts thereof, wherein W, X, Y, Z, R1, R2, R3, R4 and R5 are as described in this application, and methods of using said compounds in the treatment of cancer.
Inventors:
Chen, Xiao Chin
Donnel, Andrew F.
Kester, Robert Francis
Lee, Kang
Lowe, Yang
Michelle, Christoph
Remisewski, Stacy
Rupert, Kenneth C.
Wesel, Martin
Donnel, Andrew F.
Kester, Robert Francis
Lee, Kang
Lowe, Yang
Michelle, Christoph
Remisewski, Stacy
Rupert, Kenneth C.
Wesel, Martin
Application Number:
JP2016553729A
Publication Date:
April 15, 2020
Filing Date:
November 14, 2014
Export Citation:
Assignee:
Ef Hoffman-La Roche Akchengezel Shaft
International Classes:
C07D243/12; A61K31/551; A61P35/00; C07D401/06; C07D401/14; C07D403/06; C07D403/12; C07D405/06; C07D405/14; C07D413/06; C07D417/12; C07D487/08
Domestic Patent References:
| JP2012515713A | ||||
| JP2010520237A | ||||
| JP2008505976A |
Foreign References:
| WO2007101347A1 | ||||
| WO2006133147A1 |
Other References:
KESTER, Robert F. et al.,Optimization of Benzodiazepinones as Selective Inhibitors of the X-Linked Inhibitor of Apoptosis Protein (XIAP) Second Baculovirus IAP Repeat (BIR2) Domain,Journal of Medicinal Chemistry,2013年10月24日,56(20),7788-7803,DOI: 10.1021/jm400732v [published online 2013.10.07]
DONNELL, Andrew F. et al.,Benzazepinones and Benzoxazepinones as Antagonists of Inhibitor of Apoptosis Proteins (IAPs) Selective for the Second Baculovirus IAP Repeat (BIR2) Domain,Journal of Medicinal Chemistry,2013年10月24日,56(20) ,7772-7787,DOI: 10.1021/jm400731m [published online 2013.10.01]
DONNELL, Andrew F. et al.,Benzazepinones and Benzoxazepinones as Antagonists of Inhibitor of Apoptosis Proteins (IAPs) Selective for the Second Baculovirus IAP Repeat (BIR2) Domain,Journal of Medicinal Chemistry,2013年10月24日,56(20) ,7772-7787,DOI: 10.1021/jm400731m [published online 2013.10.01]
Attorney, Agent or Firm:
Sonoda/Kobayashi Patent Business Corporation