Title:
テトラヒドロカルバゾール及び誘導体
Document Type and Number:
Japanese Patent JP4705630
Kind Code:
B2
Abstract:
The present invention relates to compounds of the formula (I) wherein R1, R2, R3, R4, R5, X1, X2, X3, X4, n, and k are defined in the description and claims, and pharmaceutically acceptable salts and/or pharmaceutically acceptable esters thereof. The compounds are useful for in the treatment and prophylaxis of diseases which are modulated by LXRα and/or LXRβ agonists, including increased lipid and cholesterol levels, particularly low HDL-cholesterol, high LDL-cholesterol, atherosclerotic diseases, diabetes, particularly non-insulin dependent diabetes mellitus, metabolic syndrome, dyslipidemia, Alzheimer's disease, sepsis, inflammatory diseases such as colitis, pancreatitis, cholestasis/fibrosis of the liver, and diseases that have an inflammatory component such as Alzheimer's disease or impaired/improvable cognitive function.
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Inventors:
Henrietta, Damelow
Kuhn, Bernd
Raffaello, Masziadri
Panday, Narendra
Ratony, Asan
Light, matthew break
Kuhn, Bernd
Raffaello, Masziadri
Panday, Narendra
Ratony, Asan
Light, matthew break
Application Number:
JP2007504315A
Publication Date:
June 22, 2011
Filing Date:
March 17, 2005
Export Citation:
Assignee:
F. HOFFMANN-LA ROCHE AKTIENGESELLSCHAFT
International Classes:
C07D209/86; A61K31/40; A61K31/403; A61K31/422; A61K31/423; A61K31/4245; A61K31/428; A61K31/437; A61K31/4439; A61P1/00; A61P1/16; A61P1/18; A61P3/00; A61P3/06; A61P3/10; A61P9/10; A61P25/28; A61P29/00; A61P31/04; A61P43/00; C07D209/70; C07D209/88; C07D209/94; C07D401/06; C07D401/12; C07D403/06; C07D403/12; C07D411/06; C07D411/14; C07D413/06; C07D413/14; C07D417/06; C07D471/04
Foreign References:
| WO2003099821A1 | ||||
| WO2003099775A1 | ||||
| WO2003090746A1 | ||||
| WO2004011448A1 | ||||
| WO2003090732A1 |
Attorney, Agent or Firm:
Hajime Tsukuni
Fumio Shinoda
Fumio Shinoda