Title:
AMPK活性に関連する疾患を処置するためのテトラヒドロトリアジン化合物
Document Type and Number:
Japanese Patent JP5485292
Kind Code:
B2
Abstract:
The invention relates to compounds of formula (I) wherein the radicals R1 to R6 have the meaning according to claim 1, and/or physiologically acceptable salts thereof, for the prophylactic or therapeutic treatment and/or monitoring of physiological and/or pathological conditions that are associated with the activity of AMP-activated protein kinase (AMPK). Another object of the invention concerns the use of said compounds for enhancing glucose homeostasis, improving podocytopathy and/or decreasing the production of reactive oxygen species (ROS). The invention also relates to a method for in-vitro diagnosing diabetic nephropathy and a method for screening compounds that reduce podocytopathy, in each case by applying synaptopodin as biomarker.
Inventors:
Clavo, Daniel
Harakuu-Bozek, Sophie
Messan Joe, Didier
Elba Wab, Samer
Harakuu-Bozek, Sophie
Messan Joe, Didier
Elba Wab, Samer
Application Number:
JP2011540126A
Publication Date:
May 07, 2014
Filing Date:
December 11, 2009
Export Citation:
Assignee:
POXEL SAS
International Classes:
A61K31/53; A61K45/00; A61P29/00; A61P35/00; A61P43/00
Domestic Patent References:
| JP2003520858A |
Foreign References:
| WO2007079916A1 | ||||
| WO2005030735A1 | ||||
| GB2397301A | ||||
| WO1991001733A1 | ||||
| US3629467 |
Other References:
Ha H et al.,Role of reactive oxygen species in the pathogenesis of diabetic nephropathy.,Diabetes Res Clin Pract.,2008年10月 8日,Vol.82 Suppl 1,pp.42-45
Susztak K et al.,Glucose-induced reactive oxygen species cause apoptosis of podocytes and podocyte depletion at the onset of diabetic nephropathy.,Diabetes.,2006年 1月,Vol.55 No.1,pp.225-233
Wang G et al.,Urinary messenger RNA expression of podocyte-associated molecules in patients with diabetic nephropathy treated by angiotensin-converting enzyme inhibitor and angiotensin receptor blocker.,Eur J Endocrinol. ,2008年 3月,Vol.158 No.3,pp.317-322
Wang G et al.,Messenger RNA expression of podocyte-associated molecules in the urinary sediment of patients with diabetic nephropathy.,Nephron Clin Pract.,2007年 6月26日,Vol.106 No.4,pp.169-179
Cammisotto PG et al.,Control of glycogen synthase through ADIPOR1-AMPK pathway in renal distal tubules of normal and diabetic rats.,Am J Physiol Renal Physiol. ,2008年 2月 6日,Vol.294 No.4,pp.881-889
Lee MJ et al.,A role for AMP-activated protein kinase in diabetes-induced renal hypertrophy.,Am J Physiol Renal Physiol.,2006年10月 3日,Vol.292 No.2,pp.617-627
Susztak K et al.,Glucose-induced reactive oxygen species cause apoptosis of podocytes and podocyte depletion at the onset of diabetic nephropathy.,Diabetes.,2006年 1月,Vol.55 No.1,pp.225-233
Wang G et al.,Urinary messenger RNA expression of podocyte-associated molecules in patients with diabetic nephropathy treated by angiotensin-converting enzyme inhibitor and angiotensin receptor blocker.,Eur J Endocrinol. ,2008年 3月,Vol.158 No.3,pp.317-322
Wang G et al.,Messenger RNA expression of podocyte-associated molecules in the urinary sediment of patients with diabetic nephropathy.,Nephron Clin Pract.,2007年 6月26日,Vol.106 No.4,pp.169-179
Cammisotto PG et al.,Control of glycogen synthase through ADIPOR1-AMPK pathway in renal distal tubules of normal and diabetic rats.,Am J Physiol Renal Physiol. ,2008年 2月 6日,Vol.294 No.4,pp.881-889
Lee MJ et al.,A role for AMP-activated protein kinase in diabetes-induced renal hypertrophy.,Am J Physiol Renal Physiol.,2006年10月 3日,Vol.292 No.2,pp.617-627
Attorney, Agent or Firm:
Hajime Tsukuni
Fusayuki Saito
Fusayuki Saito