Title:
老化防御効果を示すテトラペプチド、これを基にした薬理学的物質、及びその利用法
Document Type and Number:
Japanese Patent JP3902406
Kind Code:
B2
Abstract:
Tetrapeptide L-alanyl-L-glutamyl-L-aspartyl-glycine (SEQ ID NO: 1) of the general formula L-Ala-L-Glu-L-Asp-Gly (SEQ ID NO: 1) is proposed as a biologically active compound with a geroprotective effect. The use of L-Ala-L-Glu-L-Asp-Gly (SEQ ID NO: 1) tetrapeptide in medicine is proposed for preparing a substance displaying a geroprotective effect. There is proposed a pharmacological substance, which contains as its active base an effective amount of tetrapeptide of the formula L-alanyl-L-glutamyl-L-aspartyl-glycine (L-Ala-L-Glu-L-Asp-Gly) (SEQ ID NO: 1) or its salts of the amino group (acetate, hydrochloride, oxalate) and of carboxyl groups (the salts of metals-Sodium, Potassium, Calcium, Lithium, Zinc, Magnesium, and also the salts of organic and inorganic cations-ammonium and triethylammonium). The substance is proposed for parenteral, intranasal, oral administration, and local application. With respect to the invention, the method of premature ageing prevention involves prophylactic and/or therapeutic administration to a patient of the pharmacological substance in doses of 0.01 to 100 mug/kg of the body weight at least once a day for a period necessary for the achievement of a therapeutic effect.
Inventors:
Cabinson, Vladimir Katskelevich
Application Number:
JP2000616229A
Publication Date:
April 04, 2007
Filing Date:
January 20, 2000
Export Citation:
Assignee:
Obschestbo S Ogranichenoi Otobetsuto Stebenostyu "Clinica Institka Bioregria Twee Gerontrogy"
International Classes:
A61K38/00; C07K5/103; A61K38/07; A61P11/06; A61P19/00; A61P39/06; A61P43/00; C07K5/10
Attorney, Agent or Firm:
Takehiko Suzue
Sadao Muramatsu
Ryo Hashimoto
Toshio Shirane
Sadao Muramatsu
Ryo Hashimoto
Toshio Shirane