Title:
潜在的な血管形成阻害剤としてのサリドマイド類似体
Document Type and Number:
Japanese Patent JP4361273
Kind Code:
B2
Abstract:
A number of thalidomide metabolites having superior anti-angiogenic properties have now been isolated and identified. In addition, thalidomide analogs that mimic the effects of the isolated and identified active thalidomide metabolites, and variations of such thalidomide analogs, have been developed. Such thalidomide analog compounds show enhanced potency in the inhibition of undesirable angiogenesis without the undesirable effects of administration of thalidomide.
Inventors:
Fig William Dee.
Agar cart
Chubert Ube
Weiss Michel
Get Show Michelle
Hecker Thomas
House Childot Sunna
Agar cart
Chubert Ube
Weiss Michel
Get Show Michelle
Hecker Thomas
House Childot Sunna
Application Number:
JP2002567927A
Publication Date:
November 11, 2009
Filing Date:
February 26, 2002
Export Citation:
Assignee:
THE UNITED STATES OF AMERICA
International Classes:
A61K31/4035; A61K31/454; A61K31/506; A61K31/513; A61P9/00; A61P35/00; A61P43/00; C07D209/48; C07D401/04; C07D403/04
Domestic Patent References:
| JP8507767A | ||||
| JP10109975A |
Other References:
SHIMAZAWA,R. et al.,Antiangiogenic activity of tumor necrosis factor-α production regulators derived from thalidomide,Biological & Pharmaceutical Bulletin,1999年,Vol.22, No.2,p.224-226
SHIBATA,Y. et al.,Phenylphthalimides with tumor necrosis factor alpha production-enhancing activity,Chemical & Pharmaceutical Bulletin,1996年,Vol.44, No.1,p.156-162
SHIBATA,Y. et al.,Phenylphthalimides with tumor necrosis factor alpha production-enhancing activity,Chemical & Pharmaceutical Bulletin,1996年,Vol.44, No.1,p.156-162
Attorney, Agent or Firm:
Hatsushi Shimizu
Toshi Gobe
Koichi Niimi
Kazuya Kawamoto
Toshi Gobe
Koichi Niimi
Kazuya Kawamoto