Title:
樹状細胞ならびに細胞標的および潜在的薬物のスクリーニングにおけるそれらの使用
Document Type and Number:
Japanese Patent JP4494778
Kind Code:
B2
Abstract:
The present invention is based on the discovery that in response to different stimuli, dendritic cells initiate various immune responses by producing different transcription profiles, e.g., IL-2 production by dendritic cells in response to a microbial stimulus. The present invention provides methods of making libraries of gene expression profiles and libraries made thereof corresponding to dendritic cell maturation in response to a microbial stimulation. The present invention provides methods for activating lymphocytes or immune responses and methods for producing Il-2 in dendritic cells or preparing dendritic cells for cell-based therapy. The present invention also provides methods and systems for screening agents affecting dendritic cell maturation. In addition, it is the discovery of the present invention that dendritic cells are targets for immunosuppressive virus infections. Accordingly, the present invention provides methods for treating immunosuppressive virus infections or immunosuppression associated with immunosuppressive virus infection. The present invention also provides methods for screening candidate therapeutic agents suitable for treating immunosuppressive virus infection using dendritic cell system.
Inventors:
Francesca Granucci
Paola Castagnoli
Degli Mariapia Esposti
Paola Castagnoli
Degli Mariapia Esposti
Application Number:
JP2003517256A
Publication Date:
June 30, 2010
Filing Date:
July 31, 2002
Export Citation:
Assignee:
Secmed SRL
International Classes:
C12N5/0784; G01N33/50; A61K35/16; A61K38/00; A61K38/20; A61K38/22; A61P31/12; A61P31/18; A61P37/04; C12N5/0781; C12N5/0783; C12N15/09; C12Q1/02; C12Q1/68; G01N33/15; A61K35/12
Foreign References:
| WO1997004802A1 |
Other References:
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J. Biol. Chem.,2001年 7月13日,vol. 276,25680-25686
Proc. Natl. Acad. Sci. USA,1999年,vol. 96,9305-9310
J. Immunol. ,1998年,vol. 161,3042-3049
Science,1997年,vol. 278,1626-1629
Proc. Natl. Acad. Sci. USA,米国,1999年,Vol.96,2268-2273
Immunol. Today,1999年 5月,Vol.20, No.5,200-203
Attorney, Agent or Firm:
Yasuhiko Murayama
Masatake Shiga
Takashi Watanabe
Shinya Mitsuhiro
Masatake Shiga
Takashi Watanabe
Shinya Mitsuhiro