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Title:
THERAPEUTIC AGENT FOR AMYOTROPHIC LATERAL SCLEROSIS
Document Type and Number:
Japanese Patent JP3889844
Kind Code:
B2
Abstract:

PROBLEM TO BE SOLVED: To obtain the subject medicine capable of treating amyotrophic lateral sclerosis by formulating methylcobalamin.
SOLUTION: This medicine is a vitamin B12 analog and contains methylcobalamin of the formula, C63H91CoN13O14P, as an active ingredient. One ampoule of this medicine contains a solution in which 15-51mg of methylcobalamin is dissolved in 1-4ml of ethanol, physical saline or buffer solution. When administrated, the above therapeutic agent containing 15-50mg of methylcobalamin is intramuscularly or intravenously injected at a dose of 0.3-1.0mg/kg once a day as body weight of 50kg. By this process, the improvement of subjective symptom is observed at 2-4 weeks after beginning of administration and also the improvement of remarkable amyotrophic lateral sclerosis, e.g. the significant increase of the amplitude of action potential of composite muscle in the nerve conduction velocity test on both side median nerves, ulnar nerves and peroneal nerves, is observed as objective findings. The side effect is not almost observed.


Inventors:
Kaji Ryuji
Application Number:
JP4160497A
Publication Date:
March 07, 2007
Filing Date:
February 10, 1997
Export Citation:
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Assignee:
Kaji Ryuji
Eisai R & D Management Co., Ltd.
International Classes:
A61K31/714; C07H23/00; A61B19/00; A61K9/08; A61K31/7135; A61P25/00; A61P25/02; A61P43/00; (IPC1-7): A61K31/68; A61K31/68; A61K31/68; A61K9/08; //C07H23/00
Domestic Patent References:
JP6256491A
JP6256490A
JP4925127A
JP4930523A
JP494669A
JP7247219A
Attorney, Agent or Firm:
Ken Takahashi