Login| Sign Up| Help| Contact|

Patent Searching and Data


Title:
THERAPEUTIC AGENT FOR CANCER
Document Type and Number:
Japanese Patent JPH10182490
Kind Code:
A
Abstract:

To obtain enhanced toxicity to cancer cells from a chemotherapy medicine, and to control harmful effects of chemotherapy medicine on normal cells, by administering a specific compound, and then administering the chemotherapy medicine to cancer cells.

First, (A) a compound, which controls proliferation of normal cells, promotes proliferation of malignant cells and is not a compound of the formula I (X and Y are each chlorine or bromine; (o) and (p) are each 0 or 1; R1 and R2 are each a 1-3C alkyl or bonded to form a nitrogen atom- containing heterocyclic ring; (n) is 1-3) in an amount sufficient to inhibit an intercellular histamine bond in normal cells is administered to an animal and then (B) a chemotherapy medicine for cancer cells is administered to the animal. A compound of formula II (R1, R1 and (n) are as shown in the formula I) is preferable as the component A. The compound of formula II is a new compound and for example, N,N-diethyl-2-[4-(4'-fluorophenone)phenoxy]ethanolamine may be cited as the compound.


Inventors:
BRANDES LORNE J
Application Number:
JP16798A
Publication Date:
July 07, 1998
Filing Date:
January 05, 1998
Export Citation:
Click for automatic bibliography generation   Help
Assignee:
UNIV MANITOBA
International Classes:
A61K31/00; A61K31/135; A61K31/138; A61K31/17; A61K31/335; A61K31/415; A61K31/445; A61K31/495; A61K31/505; A61K31/535; A61K31/54; A61K31/55; A61K45/00; A61K45/06; A61P35/00; C07C217/18; C07C217/20; C07C217/22; (IPC1-7): A61K45/06; A61K31/135; A61K31/415; A61K31/445; A61K31/54; A61K31/55; C07C217/18
Attorney, Agent or Firm:
Wakabayashi Tadashi