To provide a therapeutic agent using a capsinoid compound as an active ingredient, although the capsinoid compound is known to have various physiological activities, e.g. a blood flow-enhancing activity, a hypotensive activity, an anti-diabetic activity, etc., it is further effective to various diseases other than the above with a marked effectiveness.

This therapeutic or preventing agent of rheumatism, cancerous diseases, etc., and a calcium absorption-enhancing agent containing the capsinoid compound as the active ingredient are provided. An anti-osteoporosis agent, a preventing or treating agent of overhanging, an influenza virus infection inhibitor, an anti-depressant, an anti-stress agent, a therapeutic agent for drug dependency and an adiponectin production-enhancing agent containing the capsinoid compound as the active ingredient are also provided.