Title:
THERAPEUTIC AMIDE
Document Type and Number:
Japanese Patent JP3192228
Kind Code:
B2
Abstract:
PURPOSE: To obtain a substd. amide which is a cell potassium channel opener in mammal and which is useful for therapy of urinary incontinence.
CONSTITUTION: This is a compd. of formula I [wherein E is N or CZ (in which C is ring carbon); in the case E is CZ, (A) X is ArY (in which Y is CO, SO or SO2, Ar is a halo, OH, CN, phenyl substd. with 0 to 2 1-4C alkyls, a 6-membered heteroaryl ring having from 1 to 2 pieces of N or a 5-membered heteroaryl ring having 1 to 2 pieces of N, O or S), and Z is H, CN, a halo OH, a 1-4C alkyl, etc., or (B) X is CN and Z is phenylthio, phenylsulfinyl, etc.; or in the case E is N, X is ArY, each of R2 and R3 is a 1-3C alkyl optionally substd. with F or Cl], such as N-[4-(2-fluorophenylsulfonyl)phenyl]-3,3,3- trifluoro-2-hydroxy-2-methylpropaneamide. The compd. is obtained by coupling aniline of formula II with an acid of formula III (wherein G is OH).
Inventors:
Keith Russell
Cyrus John Ornmach
Keith Hopkinson Gibson
Cyrus John Ornmach
Keith Hopkinson Gibson
Application Number:
JP19995492A
Publication Date:
July 23, 2001
Filing Date:
July 27, 1992
Export Citation:
Assignee:
Zeneca Limited
International Classes:
A61K31/275; A61K31/38; A61K31/425; A61K31/44; A61K31/50; A61K31/505; A61P13/02; A61P15/00; C07C235/16; A61K31/165; C07C235/38; C07C255/58; C07C317/40; C07C317/44; C07C317/50; C07C323/41; C07D213/50; C07D213/70; C07D213/75; C07D239/38; C07D241/18; C07D277/36; C07D333/34; (IPC1-7): C07C235/38; A61K31/165; A61K31/275; A61P13/02; C07C255/58; C07C317/40; C07C323/41; C07D213/75
Other References:
【文献】Synthesis,(1977)No.1,p.31-p.33
Attorney, Agent or Firm:
Kazuo Shamoto (5 outside)
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