Title:
アムロジピンとベナゼプリル/ベナゼプリラートの治療上の組み合せ
Document Type and Number:
Japanese Patent JP2004519440
Kind Code:
A
Abstract:
The present invention especially relates to the use of a combination comprising (1) an ACEI selected from the group consisting of benazepril, benazeprilat, and pharmaceutically acceptable salts thereof, and (2) amlodipine or pharmaceutically acceptable salt thereof,
for the manufacture a medicament for the treatment or prevention or delay of progression of a condition selected from the group consisting of hypertension, congestive heart failure, angina, myocardial infarction, artherosclerosis, diabetic nephropathy, diabetic cardiac myopathy, renal insufficiency, peripheral vascular disease, left ventricular hypertrophy, cognitive dysfunction, blood pressure-related cerebrovasular disease, stroke, pulmonary disease or pulmonary hypertension and headache;
wherein (i) the amount of amlodipine or a pharmaceutically acceptable salt thereof corresponds to 6 mg to 40 mg of the free base and (ii) the amount of the ACE inhibitor or a pharmaceutically thereof corresponds to 20 mg to 160 mg of benazepril hydrochloride.
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Inventors:
Comfort, Ann Liese
Durley, William Lionel
Flairs, Saint Joseph
Alan Edward, Lois
Web, randy lee
Way, William Schiffing
Durley, William Lionel
Flairs, Saint Joseph
Alan Edward, Lois
Web, randy lee
Way, William Schiffing
Application Number:
JP2002550986A
Publication Date:
July 02, 2004
Filing Date:
December 17, 2001
Export Citation:
Assignee:
NOVARTIS AG
International Classes:
C07D223/16; A61K9/48; A61K31/44; A61K31/4418; A61K31/4422; A61K31/55; A61K45/06; A61K47/04; A61K47/12; A61K47/26; A61K47/32; A61K47/36; A61K47/38; A61P3/10; A61P9/00; A61P9/02; A61P9/04; A61P9/10; A61P9/12; A61P11/00; A61P13/12; A61P25/00; A61P25/04; A61P25/06; A61P25/28; A61P27/00; A61P43/00; C07D211/90; (IPC1-7): A61K31/4422; A61K9/48; A61K31/55; A61K47/04; A61K47/12; A61K47/26; A61K47/32; A61K47/36; A61K47/38; A61P3/10; A61P9/00; A61P9/04; A61P9/10; A61P9/12; A61P11/00; A61P13/12; A61P25/00; A61P25/06; A61P25/28
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Attorney, Agent or Firm:
Aoyama Aoi
Mitsutaka Iwasaki
Shoji Nakajima
Kazuaki Kojima
Mitsutaka Iwasaki
Shoji Nakajima
Kazuaki Kojima