Title:
THERAPEUTIC PROTEINS WITH INCREASED HALF-LIFE AND METHODS OF PREPARING THE SAME
Document Type and Number:
Japanese Patent JP2018162293
Kind Code:
A
Abstract:
PROBLEM TO BE SOLVED: To provide materials and methods of conjugating a water-soluble polymer to a therapeutic protein.SOLUTION: A method of preparing a therapeutic protein conjugate comprises the step of contacting a therapeutic protein, or biologically active fragment thereof, with a thiol reductant and a water-soluble polymer, or functional derivative thereof, under conditions that produce a reduced cysteine sulfhydryl group on the therapeutic protein and allow conjugation of the water-soluble polymer to the reduced cysteine sulfhydryl group.SELECTED DRAWING: None
Inventors:
SIEKMANN JUERGEN
ALFRED WEBER
HANSPETER ROTTENSTEINER
TURECEK PETER
ALFRED WEBER
HANSPETER ROTTENSTEINER
TURECEK PETER
Application Number:
JP2018120337A
Publication Date:
October 18, 2018
Filing Date:
June 26, 2018
Export Citation:
Assignee:
BAXALTA GMBH
BAXALTA INC
BAXALTA INC
International Classes:
C07K14/745; A61K38/14; A61K38/37; A61K38/38; A61K38/48; A61K47/60; A61K47/61; A61P7/04; C07K1/13; C07K14/47; C07K14/755
Domestic Patent References:
| JP2008524117A | 2008-07-10 | |||
| JP2009532351A | 2009-09-10 |
Attorney, Agent or Firm:
Yusuke Hiraki
Satoshi Fujita
Natsuo Tanaka
Naoko Kikuta
Yumi Naito
Hidetoshi Hanai
Satoko Tsuruta
Satoshi Fujita
Natsuo Tanaka
Naoko Kikuta
Yumi Naito
Hidetoshi Hanai
Satoko Tsuruta