Title:
THERAPEUTIC RECOMBINANT KLOTHO PROTEIN AND COMPOSITIONS AND METHODS COMPRISING SAME
Document Type and Number:
Japanese Patent JP2023123565
Kind Code:
A
Abstract:
To provide recombinant Klotho proteins and variants, nucleic acids encoding the same, cell lines and suspension cultures expressing the same, and method of manufacturing and administering the same.SOLUTION: Disclosed is a cell line comprising a plurality of Chinese hamster ovary (CHO) cells, where the CHO cells contain an exogenous nucleic acid, the exogenous nucleic acid comprises a promoter and encodes a medically effective polypeptide. The polypeptide comprises an N-terminal signal peptide, a recombinant human α soluble Klotho protein and a C-terminal polypeptide tag. The polypeptide or recombinant human α soluble Klotho protein is effective in the treatment of acute kidney injury, chronic renal diseases or aging-related conditions, diseases or disorders.SELECTED DRAWING: Figure 1
Inventors:
JOSEPH F TARSIO
DINESH RATURI
JAMES R PLANTE
DINESH RATURI
JAMES R PLANTE
Application Number:
JP2023096236A
Publication Date:
September 05, 2023
Filing Date:
June 12, 2023
Export Citation:
Assignee:
KLOTHO THERAPEUTICS INC
International Classes:
C12N15/12; A61K38/16; A61K47/62; A61P1/04; A61P3/10; A61P9/06; A61P11/00; A61P13/12; A61P17/00; A61P19/02; A61P19/10; A61P21/00; A61P25/00; A61P25/02; A61P25/16; A61P25/28; A61P27/02; A61P27/06; A61P27/12; A61P29/00; A61P29/02; A61P43/00; C12N5/10; C12N9/00; C12N9/06; C12N15/52; C12N15/53; C12P21/02
Attorney, Agent or Firm:
Makoto Onda
Hironobu Onda
Atsushi Honda
Miki Nakamura
Hironobu Onda
Atsushi Honda
Miki Nakamura
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