眼圧降下用の治療用置換シクロペンタン類

Japanese Patent JP5453254

B2

Disclosed herein are compounds having formula (I) wherein a dashed line represents the presence or adsence of a bond; Y is an organic acid functional group, or an amide or ester thereof; or Y is hydroxymethyl or an ester thereof; or Y is a tetrazolyl functional group; A is —(CH2)6—, cis —CH2CH═CH—(CH2)3—, or —CH2C═C—(CH2)3—, wherein 1 or 2 carbon atoms may be replaced by S or O; or A is —(CH2)m—Ar—(CH2)o—, wherein Ar is interarylene or heterointerarylene, the sum of m and o is 1, 2, 3, or 4, and wherein 1 —CH2— may be replaced by S or O, and 1 —CH2—CH2— may be replaced by —CH═CH— or —C≡C—; U1 and U2 are independently selected from —H, ═O, —OH, —F, —Cl, and —CN; and B is aryl or heteroaryl, for use as acular hypotensive agent.

JPS607602	[Title of the Invention] Medicine or a veterinarian medicine constituent which contains a prostagladin derivative as an active ingredient
JP2006526638	3-Oxa-8-azaprostaglandin analog as an intraocular pressure lowering agent
JP2007504134	Cyclohexyl prostaglandin analog as an EP4 receptor agonist

Old David W
Nugo Vin X
Holoboski mark
Posner Marie F

JP2010515212A

March 26, 2014

June 30, 2008

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ALLERGAN,INCORPORATED

A61K31/559; A61P27/06; A61P43/00; C07D277/20; C07D277/56; C07D333/40; C07D409/08

JP8501310A
JP2004538306A

WO1998058911A1
WO2006076370A1
WO2008008718A1
WO2008008660A1
WO2008008701A1
WO2007149829A1
US4149007
US3980700
WO1997030710A1

Koichi Tsujii
Sadao Kumakura
Nobuo Ogawa
Atsushi Hakoda
Kenji Asai
Kazuo Yamazaki
Satsuki Ichikawa

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