To provide a thermosetting resin composition having excellent heat resistance and high toughness.

A thermosetting resin composition contains the following components (A), (B) and (C): (A) a maleimide compound having two or more maleimide groups in a molecule; (B) a phenol compound having two or more structural units represented by general formula (4) (wherein R₁ is hydrogen or 1-6C alkyl; and R₂ is alkenyl) in a molecule; and (C) rubber particles with a core-shell structure, in which a component having a functional group reactable with at least one of the above resin compounds is disposed at the outer periphery of a core part comprising a rubber component.