Title:
リパーゼ阻害活性をもったチエノ-(1,3)-オキサジン-4-オン類
Document Type and Number:
Japanese Patent JP2005527469
Kind Code:
A
Abstract:
The use of a compound comprising formula (I), or a salt, ester, amide or prodrug thereof in the treatment of obesity and related disorders. The invention also relates to novel compounds within formula (I), to processes for preparing them and pharmaceutical compositions containing them. In formula (I): A is an optionally substituted thienyl moiety, Y is O, S, or NR2, R1 is a branched or unbranched alkyl (optionally interrupted by one or more oxygen atoms), alkenyl, alkynyl, cycloalkyl, cycloalkenyl, aryl, arylalkyl, reduced arylalkyl, arylalkenyl, heteroaryl, heteroarylalkyl, heteroarylalkenyl, reduced aryl, reduced heteroaryl, reduced heteroarylalkyl or a substituted derivative of any of the foregoing groups and R2 is hydrogen or a group as defined for R1.
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Inventors:
Hodson, Harold Francis
Dunk, Christopher Robert
Palmer, Richard Michael John
Mitchell, Dale Robert
Biroll, veronik
Hunt, Russell George
Dunk, Christopher Robert
Palmer, Richard Michael John
Mitchell, Dale Robert
Biroll, veronik
Hunt, Russell George
Application Number:
JP2003524589A
Publication Date:
September 15, 2005
Filing Date:
August 23, 2002
Export Citation:
Assignee:
Alizyme Therapeutics Limited
International Classes:
A23L3/3544; A61K31/535; A61K31/5365; A61P1/00; A61P3/04; A61P3/06; A61P3/10; A61P9/00; A61P9/12; A61P25/00; A61P43/00; C07D498/04; C07D498/14; C11D3/28; C11D3/48; C12N9/99; A23L1/30; (IPC1-7): A61K31/5365; A23L1/30; A23L3/3544; A61P1/00; A61P3/04; A61P3/06; A61P3/10; A61P9/00; A61P9/12; A61P25/00; A61P43/00; C07D498/04; C11D3/28; C11D3/48; C12N9/99
Attorney, Agent or Firm:
Takehiko Suzue
Satoshi Kono
Makoto Nakamura
Kurata Masatoshi
Takashi Mine
Yoshihiro Fukuhara
Sadao Muramatsu
Ryo Hashimoto
Satoshi Kono
Makoto Nakamura
Kurata Masatoshi
Takashi Mine
Yoshihiro Fukuhara
Sadao Muramatsu
Ryo Hashimoto