To obtain the new compound useful an intermediate for producing medicines.
This compound of formula I (R1 is an alkyl, an aryl capable of being substituted; R2 is an alkyl, an aryl or aromatic heterocyclic group capable of being substituted), e.g. (2R*,1',S*)-2-(1-benzoylamino-1-phenyl) methylthiirane. The compound of formula I is obtained by hydrolyzing a 4H-5,6- dihydro-1,3-thiazine derivative of formula II (X is a halogen) in the presence of an acid such as hydrochloric acid in water or in mixed solvents comprising water and an organic solvent (e.g. THF) at -10 to 150°C. The acid is used in an amount of 0.1-1 pt. per pt. of the reaction substrate. A trans-4,5-dihydro-1,3- thiazol derivative of formula III is also similarly hydrolyzed into the compound of formula I.
TODA TAKASHI
KARIKOMI MICHITOKU
Next Patent: CHLOROPYRIDYLCARBONYL DERIVATIVE