Title:
THIOL-REACTIVE MALEIMIDO-BASED RADIOLABELING REAGENT
Document Type and Number:
Japanese Patent JPH05194384
Kind Code:
A
Abstract:
PURPOSE: To provide new compounds useful for receptor studies, affinity labeling, immunochemistry, and as diagnostic imaging agents and radiotherapeutic drugs.
CONSTITUTION: The compounds of the formula I, e.g. the compounds of the formula III, which are obtained by, for example, reacting the compounds of the formula IV with the compounds of the formula V. In the formula I, R is the formula II [wherein (n), (m) are each 0 to 2], etc.; R2 is H, 122I, 123I, 75Br, 211At, etc.
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Inventors:
MAIKERU SHIYOROBU
Application Number:
JP15511192A
Publication Date:
August 03, 1993
Filing Date:
June 15, 1992
Export Citation:
Assignee:
MERCK & CO INC
International Classes:
A61K51/00; A61K51/04; A61K51/08; C07D207/452; G01N33/534; G01N33/566; G01N33/60; G01N33/74; C07D207/44; (IPC1-7): A61K49/02; C07D207/452; G01N33/534; G01N33/566; G01N33/60
Other References:
ANALYTICAL BIOCHEMISTRY=1991
Attorney, Agent or Firm:
Masao Okabe (5 others)