Title:
アレーンルテニウム(II)化合物及び癌の治療におけるそれらの使用
Document Type and Number:
Japanese Patent JP2008510693
Kind Code:
A
Abstract:
A ruthenium (II) compound of formula (I): or a solvate or prodrug thereof, wherein: R1, R1, R3, R4, R5 and R6 are independently selected from H, C1-7 alkyl, C5-20 aryl, C3-20 heterocyclyl, halo, ester, amido, acyl, sulfo, sulfonamido, ether, thioether, azo, amino, or R1 and R2 together with the ring to which they are attached form a saturated or unsaturated carbocyclic or heterocyclic group containing up to three 3- to 8- membered carbocyclic or heterocyclic rings, wherein each carbocyclic or heterocyclic ring may be fused to one or more other carbocyclic or heterocyclic rings; X is a neutral or negatively charged N- or S- donor ligand; Y is a counterion; m is 0 or 1; q is 1, 2 or 3; C' is C1-12 alkylene bound to two A groups; p is 0 or 1 and r is 1 when p is 0 and r is 2 when p is 1; and A and B are each independently O-donor, N-donor or S-donor ligands, and may be connected to one another. The compounds are used in cancer therapy.
Inventors:
Hab Temarian, Abraha
Sadler, Peter, John
Sadler, Peter, John
Application Number:
JP2007526570A
Publication Date:
April 10, 2008
Filing Date:
August 19, 2005
Export Citation:
Assignee:
The University Court Of The University Of Edinburgh
International Classes:
C07C211/10; A61K31/44; A61K33/24; A61P35/00; C07C15/02; C07C15/14; C07F15/00
Foreign References:
| DE19736152A1 | 1999-02-18 | |||
| WO2004005304A1 | 2004-01-15 |
Attorney, Agent or Firm:
Yusuke Hiraki
Ishii Teiji
Satoshi Fujita
Ai Fujii
Ishii Teiji
Satoshi Fujita
Ai Fujii