Title:
三環式化合物および治療におけるそれらの使用
Document Type and Number:
Japanese Patent JP2018505203
Kind Code:
A
Abstract:
本発明は、ＦＸＲに結合でき、ＦＸＲのモジュレーターとして働くことのできる新規な三環式化合物、またはその立体異性体、幾何異性体、互変異性体、Ｎ−オキシド、水和物、溶媒和物、代謝物、薬学的に許容可能な塩もしくはプロドラッグに関し、ＦＸＲが介在する疾患および／または病状の治療のための当該化合物の使用に関する。本発明はさらに、本明細書において開示される化合物を含む医薬組成物、並びに当該化合物または医薬組成物を投与することを特徴とする、ＦＸＲが介在する疾患および／または病状の治療方法を提供する。
Inventors:
Wang Xiao Jun
Yang Shin Ye
Pan Shontian
Guo Louis
Wu Jun Wen
Jean Injun
Chen Chang Chun
Yang Shin Ye
Pan Shontian
Guo Louis
Wu Jun Wen
Jean Injun
Chen Chang Chun
Application Number:
JP2017542165A
Publication Date:
February 22, 2018
Filing Date:
February 05, 2016
Export Citation:
Assignee:
SUNSHINE LAKE PHARMA CO.,LTD.
International Classes:
C07D249/04; A61K31/4155; A61K31/4192; A61K31/422; A61K31/435; A61K31/4353; A61K31/4365; A61K31/4375; A61K31/4985; A61K31/5025; A61K31/519; A61K31/55; A61K31/553; A61P1/00; A61P1/04; A61P1/16; A61P3/04; A61P3/06; A61P3/10; A61P7/00; A61P7/02; A61P7/06; A61P9/00; A61P9/04; A61P9/10; A61P9/12; A61P11/00; A61P13/12; A61P15/10; A61P17/00; A61P29/00; A61P31/20; A61P35/00; A61P43/00; C07D261/08; C07D411/12; C07D413/12; C07D471/04; C07D491/044; C07D491/052; C07D491/147; C07D497/04; C07D498/04; C07D498/14
Domestic Patent References:
| JP2010512342A | 2010-04-22 | |||
| JP2010532363A | 2010-10-07 | |||
| JP2006528637A | 2006-12-21 |
Foreign References:
| WO2007144785A2 | 2007-12-21 |
Other References:
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AKWABI-AMEYAW, ADWOA; BASS, JONATHAN Y. ET AL.: "Conformationally constrained farnesoid X receptor (FXR) agonists: Naphthoic acid-based analogs of GW", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol. 18(15), JPN6019027580, 2008, pages 4339 - 4343, ISSN: 0004077193
Attorney, Agent or Firm:
Samejima Mutsumi
Nagatoshi Shinagawa
Kure Hidenori
Mizuhara Masahiro
Kamahira Futami
Nagatoshi Shinagawa
Kure Hidenori
Mizuhara Masahiro
Kamahira Futami