Title:
トロンボキサン受容体アンタゴニスト
Document Type and Number:
Japanese Patent JP6837190
Kind Code:
B2
Abstract:
The invention relates to novel chemical entities that act as thromboxane (TX) A2 receptor, or T prostanoid receptor (TP), antagonists and to their use in the treatment of human diseases in which thromboxane (TX) A and of all other agents that act as incidental ligands of TP, including the endoperoxide prostaglandin (PG)G2/PGH2, 20-hydroxyeicosatetraenoic acid (20-HETE) and the free -radical derived isoprostanes (e.g., 8-iso-prostaglandin (PG)F2α), play a role. Compounds of the invention preferably include a benzenesulfonyl urea in which the benzene is substituted by a substituted biphenylyloxy group (e.g., at the 2 position) and by a nitrile group (e.g., at the 5 position), which compounds show promising results as TP-isoform selective TP antagonists.
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Inventors:
Kinsera, B. Therese
Reed, helen
Reed, helen
Application Number:
JP2017564898A
Publication Date:
March 03, 2021
Filing Date:
June 13, 2016
Export Citation:
Assignee:
ATX Therapeutics Limited
International Classes:
C07C311/58; A61K31/64; A61K45/00; A61L27/28; A61L27/40; A61L27/50; A61L27/54; A61L31/12; A61L31/16; A61L33/04; A61L33/14; A61P3/10; A61P7/02; A61P9/00; A61P9/10; A61P9/12; A61P11/00; A61P11/06; A61P13/08; A61P13/12; A61P29/00; A61P35/00; A61P43/00
Domestic Patent References:
| JP2004513155A | ||||
| JP2010527331A |
Foreign References:
| WO2013156871A1 | ||||
| US6818765 |
Attorney, Agent or Firm:
Hidesaku Yamamoto
Natsuki Morishita
Takatoshi Iida
Daisuke Ishikawa
Kensaku Yamamoto
Natsuki Morishita
Takatoshi Iida
Daisuke Ishikawa
Kensaku Yamamoto