Title:
強力なＲＯＣＫ阻害剤としてのタイドバックのベンズアミド誘導体
Document Type and Number:
Japanese Patent JP6633618
Kind Code:
B2
Abstract:
The present invention provides compounds of Formula (I) or stereoisomers, tautomers, or pharmaceutically acceptable salts thereof, wherein all the variables are as defined herein. These compounds are selective ROCK inhibitors. This invention also relates to pharmaceutical compositions comprising these compounds and methods of treating cardiovascular, smooth muscle, oncologic, neuropathologic, autoimmune, fibrotic, and/or inflammatory disorders using the same.
Inventors:
Jirung Who
Dolly F Sitokov
Mimi El Kwan
Dolly F Sitokov
Mimi El Kwan
Application Number:
JP2017510314A
Publication Date:
January 22, 2020
Filing Date:
August 20, 2015
Export Citation:
Assignee:
BRISTOL-MYERS SQUIBB COMPANY
International Classes:
C07D401/10; A61K31/4155; A61K31/416; A61K31/422; A61K31/437; A61K31/4439; A61K31/454; A61K31/496; A61P1/04; A61P9/00; A61P9/04; A61P9/10; A61P9/12; A61P11/06; A61P15/10; A61P25/00; A61P27/06; A61P29/00; A61P35/00; A61P37/02; A61P37/06; A61P43/00; C07D401/14; C07D403/10; C07D403/14; C07D405/14; C07D409/14; C07D413/14
Domestic Patent References:
| JP2012529470A | ||||
| JP2010536925A | ||||
| JP2007519754A |
Foreign References:
| WO2014012614A1 | ||||
| WO2014089379A1 |
Other References:
Liang, Jun et al.,Lead Optimization of a 4-Aminopyridine Benzamide Scaffold To Identify Potent, Selective, and Orally Bioavailable TYK2 Inhibitors,Journal of Medicinal Chemistry,2013年,Vol.56, No.11,p.4521-4536
REGISTRY(STN)[online],2014.06.13[検索日 2019.04.15]CAS登録番号 1610586-62-3
REGISTRY(STN)[online],2014.06.13[検索日 2019.04.15]CAS登録番号 1610586-62-3
Attorney, Agent or Firm:
Samejima Mutsumi
Nagatoshi Shinagawa
Kure Hidenori
Mizuhara Masahiro
Nagatoshi Shinagawa
Kure Hidenori
Mizuhara Masahiro