To increase the safety of a tissue piece sampling device for endoscope by making it possible to provide high cutting characteristics for hardened tissue pieces and flexible tissue layers and to securely take out the cut tissue piece from the body as well as to impose physical restriction to the degree of invasion of the cutting tool.

A tissue piece sampling device for endoscope has a drill blade (3) made of a spiral blade attached to a tip end of a wire (4) inserted into an outer cylinder part (1), an inner cylinder part (2) being inserted into the outer cylinder part (1), with a rotation stop connection made in the front side. An outer periphery of the drill blade has an external diameter substantially equal to an inner periphery of the inner cylinder part (2). A cut tissue piece is transferred to a reception pocket (6), along a spiral passage formed between a spiral groove of the drill blade (3) and an inner peripheral surface of the inner cylinder part (2) when the drill blade (3) is rotationally driven by way of the wire (4). When the reception pocket (6) is filled with tissue pieces, tissue pieces are no more transferred by the drill blade (3) to thereby suppress the cutting of tissue pieces.