Title:
組織特異的および病原菌特異的毒性剤、リボザイム、DNAzymeおよびアンチセンスオリゴヌクレオチドとそれらの使用方法
Document Type and Number:
Japanese Patent JP2004525602
Kind Code:
A
Abstract:
The present invention relates to the discovery, identification and characterization of toxic agents which are lethal to pathogens and methods for targeting such toxic agents to a pathogen or pathogen infected cells in order to treat and/or eradicate the infection. In particular, the present invention relates to toxic agents which target bacteria at different stages of the bacterial life cycle, which are delivered alone or in combination to bacteria or bacteria-infected cells. The invention relates to toxic agents which are lethal to diseased cells and methods for targeting such toxic agent to a diseased cell in order to treat and/or eradicate the disease. The present invention relates to promoter elements which are pathogen-specific or tissue-specific and the use of such promoter elements to achieve pathogen-specific or tissue-specific expression of the toxic agent(s) and/or ribozyme(s) of the present invention. Specifically, the invention relates to the delivery of one or more toxic gene products, antisense RNAs, or ribozymes, or combination thereof. The invention provides a novel system by which multiple pathogenic targets may be simultaneously targeted to cause the death of a pathogen, or cell infected with a pathogen. Further, the invention has important implications in the eradication of drug-resistant bacterium and bacterial pathogens. The invention provides a novel system by which multiple targets may be simultaneously targeted to cause the death of a diseased cell. The invention has important implications in the eradication of drug-resistant pathogens (such as antibiotic resistant bacteria) and drug-resistant diseased cells (such as drug-resistant cancer cells).
Inventors:
Norris James S.
Clauson Gray A.
West Water Caroline
Scofield david
Schmidt Michael G.
Hoel Bryan
Dolan Joseph
Pan Way-Hoa
Clauson Gray A.
West Water Caroline
Scofield david
Schmidt Michael G.
Hoel Bryan
Dolan Joseph
Pan Way-Hoa
Application Number:
JP2001577507A
Publication Date:
August 26, 2004
Filing Date:
April 13, 2001
Export Citation:
Assignee:
Medical University of South Carolina
The Penn State Research Foundation
The Penn State Research Foundation
International Classes:
C12N15/09; A61K9/06; A61K9/127; A61K31/7088; A61K31/7105; A61K47/42; A61K48/00; A61P1/16; A61P15/00; A61P17/12; A61P31/04; A61P31/12; A61P33/00; A61P35/00; C12N9/00; C12N15/113; C12N15/74; A61K38/00; (IPC1-7): C12N15/09; A61K9/06; A61K9/127; A61K31/7088; A61K31/7105; A61K47/42; A61K48/00; A61P1/16; A61P15/00; A61P17/12; A61P31/04; A61P31/12; A61P33/00; A61P35/00; C12N9/00
Attorney, Agent or Firm:
Hatsushi Shimizu
Kazunori Hashimoto
Kazunori Hashimoto