Title:
TISSUE TYPE PLASMINOGEN ACTIVATOR MUTANT
Document Type and Number:
Japanese Patent JPS62192323
Kind Code:
A
Abstract:
The invention relates to tissue-type plasminogen activator (t-PA) mutants having improved binding characteristics towards fibrin. The binding of t-PA to fibrin is due to the kringle K2 domain and, to a lesser extent, to the finger domain F. The claimed mutants either comprise at least one K2 or at least one F domain and lack one or more other parts of the t-PA molecule, or comprise at least two K2 or F domains, or comprise at least one modified K2 or F domain having improved binding characteristics towards fibrin. The invention also relates to a process for preparing said mutants by genetic engineering and to the recombinant genetic information used therein. Further, the invention relates to the use of said mutants in therapy or imaging and to pharmaceutical compositions suitable therefor.
Inventors:
PANNEKOEK HANS (NL)
VEERMAN ARNOLDUS JOHANNES G (NL)
ZONNEVELD ANTON JAN VAN (NL)
VEERMAN ARNOLDUS JOHANNES G (NL)
ZONNEVELD ANTON JAN VAN (NL)
Application Number:
JP7263086A
Publication Date:
August 22, 1987
Filing Date:
April 01, 1986
Export Citation:
Assignee:
STICHTING CENTRAAL LAB (NL)
International Classes:
A61K38/46; C12N9/64; C12N9/72; A61K35/12; (IPC1-7): A61K35/12; A61K35/74; A61K37/54
Attorney, Agent or Firm:
Heiyoshi Odashima