To provide tissue which makes itself as a popular item and resolves such a problem that following tissue does not come out, and to provide a tissue box.

A user can be excited every using time by various letters and pictures printed on a sheet of paper unexpectedly coming out from a box. By adding such value-added, a purchase desire grows up and the user is attracted to come to the shop again by exchanging it with a gift or new tissue causing to make it a topic among family members and friends to increase repeaters. On the other hand, by coloring a resin film part 2 in a take-out opening on the upper part of the box into two colors, widening one part of the two-divided resin film 2 than the other part, and finely notch cutting two overlapping ends of the resin film 2, coming out letters and pictures are securely taken out without falling the taken out tissue 1.