Title:
【発明の名称】1,2-置換されたエルゴリン誘導体、該製法及び該誘導体を含有する精神分裂同型団精神病及び抑うつ症治療剤
Document Type and Number:
Japanese Patent JPH0670051
Kind Code:
B2
Abstract:
The disclosure relates to 1,2-substituted ergoline derivatives of general Formula I (I) wherein X is an oxygen or sulfur atom, R1 is a lower alkyl group, R2 is halogen, acyl, a saturated or unsaturated lower alkyl group which can optionally be substituted by OR4 wherein R4 is hydrogen, lower alkyl, tetrahydropyranyl or cycloalkyl, or by an optionally substituted aryl residue, an S-R5-group wherein R5 means a lower alkyl group which can optionally be substituted by aryl or an optionally substituted aryl residue, a wherein n=2 o4 3, or a -CHO-group, R3 is lower alkyl or acyl, and C9-C10 is a CC-single or a CC-double bond, and the hydrogen atom in the 10-position is in the alpha -location if C9-C10 is a CC-single bond, as well as the acid addition salts thereof. The compounds exhibit valuable pharmacological properties.
Inventors:
Andreas Hoot
Gerhard Sauer
Helmut Wuerter
Gerhard Sauer
Helmut Wuerter
Application Number:
JP23469386A
Publication Date:
September 07, 1994
Filing Date:
October 03, 1986
Export Citation:
Assignee:
Schie-Ring Actien Gezershaft
International Classes:
A61K31/48; A61P25/18; A61P25/24; A61P25/26; C07D457/12; (IPC1-7): C07D457/12; A61K31/48
Attorney, Agent or Firm:
Toshio Yano (1 outside)
Next Patent: ８α−アシルアミノエルゴリン、その製法と医薬