Title:
【発明の名称】17-アルキル-7-置換-4-アザステロイド誘導体
Document Type and Number:
Japanese Patent JPH11513711
Kind Code:
A
Abstract:
The novel compounds of the present invention are those of structural formula (I), or a pharmaceutically acceptable salt, or stereoisomer thereof, which are inhibitors of 5 alpha -reductase, particularly 5 alpha -reductase type 1. The compounds of formula (I) are useful in the systemic, including oral, or parenteral or topical treatment of hyperandrogenic conditions such as acne vulgaris, seborrhea, androgenic alopecia which includes female and male pattern baldness, female hirsutism, benign prostatic hyperplasia, and the prevention and treatment of prostatic carcinoma, as well as in the treatment of prostatitis. Methods of using the compounds of formula (I) for the treatment of hyperandrogenic conditions such as acne vulgaris, seborrhea, androgenic alopecia, male pattern baldness, female hirsutism, benign prostatic hyperplasia, and the prevention and treatment of prostatic carcinoma, as well as the treatment of prostatitis are provided, as well as pharmaceutical compositions for the compounds of formula (I). The use of compounds of formula (I) in combination with other active agents, for example with a 5 alpha -reductase type 2 inhibitor such as finasteride or epristeride, or a potassium channel opener, such as minoxidil, or a retinoic acid or a derivative thereof is also taught, wherein such combinations would be useful in one or more of the above-mentioned methods of treatment or pharmaceutical compositions.
Inventors:
Harris, The Georgia
Safu, Somiya Pee
Tolman, Lithium El
Safu, Somiya Pee
Tolman, Lithium El
Application Number:
JP51668097A
Publication Date:
November 24, 1999
Filing Date:
October 18, 1996
Export Citation:
Assignee:
Merck End Company, Inc.
International Classes:
A61K31/00; A61P5/28; C07D221/18; A61K31/58; C07J73/00; (IPC1-7): C07J73/00; A61K31/00; A61K31/58
Attorney, Agent or Firm:
Yoshio Kawaguchi (1 person outside)