Title:
【発明の名称】2-フェニルベンズイミダゾールおよび2-フェニルインドール、その製造方法ならびに使用
Document Type and Number:
Japanese Patent JP2002529537
Kind Code:
A
Abstract:
2-Phenylbenzimidazoles and 2-phenylindoles of formula IwhereinA is N or CH,R1 is hydrogen or alkyl which optionally carries an OR11 group,R11 is hydrogen or alkyl,R2 is hydrogen, chlorine, fluorine, bromine, iodine, alkyl, nitro, CF3, CN, NR21R22, NH-CO-R23, OR21,R21 and R22 are each hydrogen or alkyl,R23 is hydrogen, alkyl or phenyl,R3 is -(CH2)q-NR31R32,q is 0, 1, 2 or 3,R31 is hydrogen, alkyl, (CH2)rNR33R34,R32 is (CH2)rNR33R34,r is 2, 3, 4, 5 or 6,R33 and R34 are each hydrogen, alkyl or phenylalkyl wherein the phenyl ring is optionally substituted, orR33 and R34 and the nitrogen atom form a 3- to 8-membered ring,R4 is hydrogen, alkyl, chlorine, bromine, fluorine, nitro, cyano, NR41R42, NH-CO-R43, OR41,R41 and R42 are each hydrogen or alkyl, andR43 is alkyl or phenyl,are useful as inhibitors of poly(ADP-ribose)polymerase and for the production of drugs.
Inventors:
Wilfried Rubisch
Michael cock
Thomas hager
Michael cock
Thomas hager
Application Number:
JP2000582371A
Publication Date:
September 10, 2002
Filing Date:
November 05, 1999
Export Citation:
Assignee:
BASF Akchen Gezel Shaft
International Classes:
A61K31/10; A61K31/404; A61K31/41; A61K31/4184; A61K31/454; A61P3/10; A61P7/02; A61P9/00; A61P13/12; A61P25/00; A61P25/08; A61P25/14; A61P25/16; A61P25/28; A61P29/00; C07D235/18; A61P31/00; A61P35/00; A61P35/04; A61P37/02; A61P43/00; C07D209/14; C07D235/04; A61K; A61P; C07D; (IPC1-7): C07D235/18; A61K31/404; A61K31/4184; A61P3/10; A61P7/02; A61P9/00; A61P13/12; A61P25/08; A61P25/14; A61P25/16; A61P25/28; A61P29/00; A61P31/00; A61P35/00; A61P35/04; A61P37/02; A61P43/00
Attorney, Agent or Firm:
Toshio Yano (4 outside)