Title:
【発明の名称】2-ピラゾリン-5-オン
Document Type and Number:
Japanese Patent JP2003506368
Kind Code:
A
Abstract:
Chemical compounds having structural formula (I) and physiologically acceptable salts thereof, are inhibitors of serine/threonine and tyrosine kinase activity. Several of the tyrosine kinases, whose activity is inhibited by these chemical compounds, are involved in angiogenic processes. Thus, these chemical compounds can ameliorate disease states where angiogenesis or endothelial cell hyperproliferation is a factor. These compounds can be used to treat cancer and hyperproliferative disorders.
Inventors:
Marina Eme, Mosset
Berlanga, Jose Maria Castegiano
Isabel Ehue, Fernandez
Colddown, David J. Ray
Laughertei, Paul
Arnold lee
Berlanga, Jose Maria Castegiano
Isabel Ehue, Fernandez
Colddown, David J. Ray
Laughertei, Paul
Arnold lee
Application Number:
JP2001514324A
Publication Date:
February 18, 2003
Filing Date:
July 28, 2000
Export Citation:
Assignee:
Basuf Actien Gezershaft
International Classes:
A61K31/4152; A61K31/4155; A61K31/4178; A61K31/422; A61K31/428; A61K31/437; A61K31/4439; A61K31/4709; A61K31/497; A61K31/501; A61K31/506; A61K31/5377; A61P1/00; A61P1/04; A61P1/14; A61P1/16; A61P3/10; A61P3/12; A61P5/14; A61P5/16; A61P7/00; A61P7/10; A61P9/10; A61P9/14; A61P11/00; A61P15/00; A61P17/02; A61P17/06; A61P19/02; A61P27/02; A61P27/06; A61P29/00; A61P31/04; A61P35/00; A61P35/02; A61P37/08; A61P43/00; C07D231/20; C07D401/06; C07D401/14; C07D403/06; C07D403/14; C07D405/14; C07D409/06; C07D409/14; C07D413/14; C07D417/14; C07D471/04; (IPC1-7): C07D231/20; A61K31/4152; A61K31/4155; A61K31/4178; A61K31/422; A61K31/428; A61K31/437; A61K31/4439; A61K31/4709; A61K31/497; A61K31/501; A61K31/506; A61K31/5377; A61P1/00; A61P1/04; A61P1/14; A61P1/16; A61P3/10; A61P3/12; A61P5/14; A61P5/16; A61P7/00; A61P7/10; A61P9/10; A61P9/14; A61P11/00; A61P15/00; A61P17/02; A61P17/06; A61P19/02; A61P27/02; A61P27/06; A61P29/00; A61P31/04; A61P35/00; A61P35/02; A61P37/08; A61P43/00; C07D401/06; C07D401/14; C07D403/06; C07D403/14; C07D405/14; C07D409/06; C07D413/14; C07D417/14; C07D471/04
Attorney, Agent or Firm:
Yoshio Kawaguchi (5 outside)