Title:
【発明の名称】20-アルアルキル-5α-プレグナン誘導体
Document Type and Number:
Japanese Patent JP2001526673
Kind Code:
A
Abstract:
The invention relates to 20-aralkyl-5alpha-pregnane derivative having general formula (I), or a pharmaceutically acceptable salt thereof, wherein R1 is (H,OR), (H,OSO3H) or NOR; R is H, (C1-6)alkyl or (C1-6)acyl; each of R2 and R3 is independently hydrogen or (C1-6)alkyl; X is a straight chain divalent C1-8 hydrocarbon radical, optionally comprising a double or a triple bond; or X is -(CH2)m-CR7R8-; m=0-4; at least one of R7 and R8 is (C1-4)alkyl, hydroxy, (C1-4)alkoxy or halogen; the other, if present, being hydrogen; or R7 and R8 together represent O or NOR'; R' is H, (C1-6)alkyl or (C1-6)acyl; each of R4, R5 and R6 is independently hydrogen, hydroxy, (C1-4)alkoxy, halogen, NR9, R10 or (C1-4)alkyl, optionally substituted by hydroxy, alkoxy, halogen or oxo; each of R9 and R10 is independently hydrogen or (C1-4)alkyl; and the dotted lines indicate a DELTA7 or a DELTA8 double bond, or a pair of conjugated double bonds selected from DELTA7,14, DELTA8,14 and DELTA6,8(14). The compounds of the invention have meiosis activating activity and can be used for the control of fertility.
Inventors:
Laem Heiss, Johannes Antonius Joseph
Juan del Lou, Jap
Flune, Marinus Bernardo
Juan del Lou, Jap
Flune, Marinus Bernardo
Application Number:
JP54995898A
Publication Date:
December 18, 2001
Filing Date:
May 11, 1998
Export Citation:
Assignee:
Akzo Novel N B
International Classes:
A61P15/00; A61P43/00; C07J9/00; C07J31/00; C07J41/00; C07J51/00; A61K31/575; (IPC1-7): C07J9/00; A61K31/575; A61P15/00; A61P43/00; C07J31/00; C07J41/00
Attorney, Agent or Firm:
Yoshio Kawaguchi (2 outside)