Title:
【発明の名称】2,5-置換アリールピロール、この化合物を含有する組成物及び使用方法
Document Type and Number:
Japanese Patent JPH11510511
Kind Code:
A
Abstract:
The present invention addresses 2,5-substituted aryl pyrroles of formula (I); or pharmaceutically acceptable salts thereof, as well as compositions containing such compounds and methods of treatment. The compounds are useful for treating Cytokine mediated diseases, which refers to diseases or conditions in which excessive or unregulated production or activity of one or more cytokines occurs. Interleukin-1(IL-1), Interleukin-6 (IL-6), Interleukin-8 (IL-8) and Tumor Necrosis Factor (TNF) are cytokines which are involved in immunoregulation and other physiological conditions, such as inflammation. The compounds also have glucagon antagonist activity.
Inventors:
De ratzuero, stephen y
Mantro, Nathan Bey
Ponte Cielo, The Herald S
Sernitsk, Harold Gee
Riverton, Niger El Jay
Mantro, Nathan Bey
Ponte Cielo, The Herald S
Sernitsk, Harold Gee
Riverton, Niger El Jay
Application Number:
JP50866197A
Publication Date:
September 14, 1999
Filing Date:
August 06, 1996
Export Citation:
Assignee:
Merck End Company, Inc.
International Classes:
A61K31/00; A61K31/44; A61K31/4427; A61K31/443; A61K31/4433; A61K31/4439; A61K31/445; A61K31/4465; A61K31/4523; A61K31/4545; A61K31/47; A61K31/4709; A61K31/495; A61K31/496; A61K31/505; A61K31/506; A61K31/535; A61K31/5375; A61K31/5377; A61P1/00; A61P1/04; A61P9/00; A61P19/00; A61P29/00; A61P31/00; A61P37/00; A61P43/00; C07D401/04; C07D401/14; C07D403/04; C07D405/14; C07D409/14; C07D413/14; C07D471/04; (IPC1-7): C07D401/04; A61K31/00; A61K31/44; A61K31/445; A61K31/47; A61K31/495; A61K31/505; A61K31/535; C07D401/14; C07D403/04; C07D405/14; C07D409/14; C07D413/14; C07D471/04
Attorney, Agent or Firm:
Yoshio Kawaguchi (1 person outside)