Title:
【発明の名称】5―酸素化―2,4,6―トリアミノピリミジン類
Document Type and Number:
Japanese Patent JPH05503705
Kind Code:
A
Abstract:
The present invention discloses 5-oxygenated amino substituted pyrimidines (X), where R1 is (1) steroid substituent of formula (Steroid), (2) trolox substituent of formula (trolox), (3) an alkyl substituent selected from the group consisting of (A)Q2-(CH2)n2. Also disclosed are the oxygenated N,N-disubstituted pyrimidines (XIII) all of which are useful for treating a number of conditions including head injury, stroke, spinal cord injury, etc. Useful intermediates including the protected 5-oxygenated pyrimidines (VII) and the 5-oxygenated pyrimidines (VIII) are also disclosed. Further disclosed are 5-hydroxy amino substituted pyrimidines (XI).
Inventors:
McCall, John Michael
Jacobsen, Eric John
Jacobsen, Eric John
Application Number:
JP50435191A
Publication Date:
June 17, 1993
Filing Date:
January 08, 1991
Export Citation:
Assignee:
The Up John Company
International Classes:
A61K31/505; A61K31/57; A61P3/06; A61P43/00; C07D239/50; C07D403/12; C07D405/12; C07J43/00; (IPC1-7): A61K31/505; A61K31/57; C07D239/50; C07D403/12; C07D405/12; C07J43/00
Attorney, Agent or Firm:
Aoyama Ryo (1 person outside)