Title:
【発明の名称】5‐アリールイソキサゾール‐4‐イル‐置換された2‐アミノカルボン酸化合物
Document Type and Number:
Japanese Patent JPH09504531
Kind Code:
A
Abstract:
2-Aminocarboxylic acid compounds substituted with 5-arylisoxazol-4-yl or 5-arylisothiazol-4-yl and having general formula (I), wherein A is a bond or a spacer group; B is a group -CH(NR'R'')-COOH wherein R' and R'' are independently hydrogen or C1-6 alkyl, or B is a group of formula (II), wherein R2, R3 and R4 are substituents; or R3 and R4 or R4 and R2 are connected in order to form a ring; E is O, S, COO, (CH2)n-COO, O-(CH2)n-COO or S-(CH2)n-COO wherein n is 1-6, 5-tetrazolyl, 5-tetrazolyl-C1-6 alkyl, 3-hydroxyisoxazolyl or 3-hydroxyisoxazolyl-C1-6 alkyl; D is O or S; and R1 is an optionally substituted aryl or heteroaryl group; are excitatory amino acid receptor ligands useful in the treatment of cerebral ischaemia, Huntington's disease, epileptic disorders, Parkinson's disease, Alzheimer's disease, schizophrenia, pain, depression and anxiety.
Inventors:
Morzen Lentz Sybile
Falph Erik
Begges Klaus Peter
Crogs Goal-Larsen Paul
Falph Erik
Begges Klaus Peter
Crogs Goal-Larsen Paul
Application Number:
JP51297095A
Publication Date:
May 06, 1997
Filing Date:
November 02, 1994
Export Citation:
Assignee:
Her Lundbeck Actieselskab
International Classes:
A61K31/42; A61K31/422; A61K31/425; A61K31/496; A61K31/505; A61P9/10; A61P25/00; A61P25/08; A61P25/14; A61P25/18; C07D275/02; A61P25/24; A61P25/26; A61P25/28; C07D261/10; C07D261/12; C07D261/18; C07D413/04; C07D413/14; C07D417/04; (IPC1-7): C07D261/12; A61K31/42; A61K31/425; A61K31/505; C07D261/10; C07D261/18; C07D275/02; C07D275/03; C07D413/04; C07D413/14
Attorney, Agent or Firm:
Mitsuyoshi Esaki (3 outside)