Title:
【発明の名称】7-置換4-アザコラン酸誘導体とその使用
Document Type and Number:
Japanese Patent JPH10507755
Kind Code:
A
Abstract:
Compounds of the Formula I I wherein: the dotted line indicates that a double bond may be present or absent; R1 is H, methyl or ethyl; R2 is alpha - or beta -C1-10 straight or branched alkyl; R3 is CO2H, CN, CO2R4, COHNR4, or CON(R4)2; R4 is H, C1-10 straight or branched alkyl, aryl, heteroaryl, or aralkyl; Aryl is phenyl, substituted phenyl, naphthyl, or biphenyl; Heteroaryl is pyridyl, pyrrolyl, thienyl, furanyl or quinolinyl; and Aralkyl is C1-10alkyl substituted with one to three phenyl or substituted phenyl moieties; and their pharmaceutically acceptable salts are described. These compounds are 5 alpha -reductase type 1 inhibitors. They may be used for treating conditions associated with an excess of DHT, either alone or in combination with other 5 alpha -reductase inhibitors.
Inventors:
Graham, Donald Davryu
Tolman, Lithium El
Carlin, Josephine Earl
Chiiu, Shingetsu-Hin Lee
Tolman, Lithium El
Carlin, Josephine Earl
Chiiu, Shingetsu-Hin Lee
Application Number:
JP51398696A
Publication Date:
July 28, 1998
Filing Date:
October 20, 1995
Export Citation:
Assignee:
Merck End Company, Inc.
International Classes:
A61K31/47; A61K31/473; A61K31/58; C07D221/18; C07C69/00; C07J9/00; C07J73/00; (IPC1-7): C07J9/00; A61K31/47; C07D221/18
Attorney, Agent or Firm:
Yoshio Kawaguchi (3 outside)