PREPARATION OF ALPHA-IODOKETONE - MITSUBISHI CHEM IND

Title:

PREPARATION OF ALPHA-IODOKETONE

Document Type and Number:

Japanese Patent JPS5821699

Kind Code:

A

Abstract:

PURPOSE: To obtain an α-iodoketosteroid as an intermediate for preparing adrenocortical hormones, e.g. prednisolone, by reducing an α,α-diiodoketosteroid with a dithionite.

CONSTITUTION: An ethynylsteroid of formulaI(the dotted line is single or double bond), e.g. 17β-ethynyl-17α-hydroxyandrosta-1,4-dien-3-one 17-acetate, is reacted with iodonium ions to give an α,α-diiodoketosteroid, e.g. 21,21-diiodo-17α- hydroxypregna-1,4-diene-3,20-dione 17-acetate, which is then mixed with a dithionite, e.g. sodium hydrosulfite, to afford the aimed α-iodoketosteroid, e.g. 21-iodo- 17α-hydroxypregna-1,4-diene-3,20-dione 17-acetate, of formula III.

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Inventors:

NITSUTA KAZUMASA
FUJIMORI SHINICHIROU
HARUYAMA TOSHIO
INOUE SHINYA

Application Number:

JP11834481A

Publication Date:

February 08, 1983

Filing Date:

July 28, 1981

Export Citation:

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Assignee:

MITSUBISHI CHEM IND

International Classes:

C07C45/61; C07B31/00; C07B35/06; C07C45/00; C07C67/00; C07J7/00; (IPC1-7): C07C45/61; C07J7/00

Attorney, Agent or Firm:

Hajime Hasegawa

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