Title:
【発明の名称】病原体又は日和見感染微生物に対する接着受容体
Document Type and Number:
Japanese Patent JPH06501383
Kind Code:
A
Abstract:
Disclosed herein are receptors for pathogenic or opportunistic microorganisms, methods of obtaining such reeptors, and methods of using such receptors for diagnostic or pharmaceutical purposes. The receptor comprises a substantially pure compound selected from the group consisting of GalB1-4GlcNAcB1-3GalB1-4GlcB1-1-X(R), GalB1-3GlcNAcB1-3GalB1-4GlcB1-1-X(R), GlcNAcB1-3GalB1-4GlcB1-1-X(R), GalB1-4GlcNAcB1-3GalB1-4Glc, GalB1-3GlcNAcB1-3GalB1-4Glc, GlcNAcB1-3GalB1-4Glc, GalB1-4GlcNAcB1-3Gal, and GalB1-3-GlcNAcB1-3Gal wherein X is sphingosine, hydroxylated sphingosine, or saturated sphingosine and R is H or an N-acyl fatty acid derivative of X such that X(R) is a ceramide. The invention further comprises proteins and polypeptides that bind to the receptors, methods of obtaining such proteins or polypeptides from natural sources or through recombinant DNA techniques, and methods of using the purified proteins and polypeptides for pharmaceutical and diagnostic purposes, preferably in a vaccine for administration to an animal or human host to protect against pathogenic or opportunistic microorganisms.
Inventors:
Craivan Howard Sea
Samuel James Y
Samuel James Y
Application Number:
JP51506191A
Publication Date:
February 17, 1994
Filing Date:
July 29, 1991
Export Citation:
Assignee:
Microcurve ink
International Classes:
A61K9/08; A61K9/127; A61K38/00; A61K39/02; A61K39/395; A61P31/04; C07H3/06; C07H15/10; C07K14/00; C07K14/005; C07K14/195; C07K14/41; C07K14/705; C07K16/00; C07K19/00; C12N5/10; C12P21/00; G01N33/53; G01N33/566; G01N33/569; A61K39/00; (IPC1-7): C12P21/00; A61K9/08; A61K9/127; A61K37/02; A61K39/02; A61K39/395; C07K15/04; C07K15/12; C12N5/00; C12N15/31; G01N33/53; G01N33/566; G01N33/569
Attorney, Agent or Firm:
Kenji Yoshida (2 outside)