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Title:
【発明の名称】アンギオテンシン▲II▼拮抗薬の改良
Document Type and Number:
Japanese Patent JP2935740
Kind Code:
B2
Abstract:
This invention provides phenyl and heterocyclic derivatives of the formula or a pharmaceutically acceptable salt or solvate thereof each of A1, A2, and A3 is independently N or CH; X is -CO-, -CONH-, -NHCO-, -CH2 CONH-, -O-, -NH-, -CH2-each R1 is independently - (CH2)nR3; R2 is C4-C7 straight chain alkyl; each R3 is independently -OH, -COOH, or 5-tetrazolyl; each n is independently 0, 1, 2, 3, or 4; R4 is H, OH, halo, nitro, methyl, amino, acetamido, or methanesulfonamido; Q is a bond or -O-; and w is H, methyl, ethyl, or hydroxy. Their pharmaceutical formulations and their use for antagonizing angiotensin II receptors in mammals.

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Inventors:
SHERIRU RIN RAIFUAA
UINSUTON SUTANREE MAASHARU
FUARIBORUTSU MOHAMADEI
JON KEBIN RIIRU
RICHAADO RII SAIMON
MITSUCHERU AAUIN SUTAINBAAGU
SERIA AN HOWAITOSHITSUTO
Application Number:
JP33686490A
Publication Date:
August 16, 1999
Filing Date:
November 29, 1990
Export Citation:
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Assignee:
IIRAI RIRII ANDO CO
International Classes:
A61K31/00; A61K31/085; A61K31/13; A61K31/16; A61K31/18; A61K31/19; A61K31/35; A61K31/352; A61K31/40; A61K31/41; A61K31/415; A61P5/00; A61P9/00; A61P9/08; A61P9/10; A61P9/12; A61P43/00; C07C63/331; C07C65/24; C07C65/34; C07C69/76; C07C205/56; C07C229/42; C07C235/24; C07C255/41; C07D207/34; C07D231/12; C07D231/14; C07D231/20; C07D231/38; C07D233/88; C07D233/90; C07D249/04; A61K31/075; C07D249/06; C07D249/08; C07D249/10; C07D249/12; C07D249/14; C07D257/04; C07D257/06; C07D311/82; C07D311/84; C07D311/86; C07D311/88; C07D403/04; C07D403/06; C07D403/12; C07D405/06; C07D405/12; (IPC1-7): C07C63/331; A61K31/00; A61K31/075; A61K31/085; A61K31/13; A61K31/16; A61K31/18; A61K31/19; A61K31/35; A61K31/40; A61K31/41; A61K31/415; C07C65/24; C07C65/34; C07C69/76; C07C235/24; C07C255/41; C07D207/34; C07D231/12; C07D233/88; C07D233/90; C07D249/08; C07D257/04; C07D257/06; C07D311/82; C07D311/84; C07D311/86; C07D311/88; C07D403/06; C07D405/06; C07D405/12
Attorney, Agent or Firm:
Aoyama Ryo (1 person outside)



 
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