Title:
【発明の名称】アンジオテンシンII介在性諸疾患の予防または治療剤
Document Type and Number:
Japanese Patent JP3057471
Kind Code:
B2
Abstract:
PURPOSE:To provide an agent for the prevention or treatment of angiotensin II-mediated diseases, having suppressed side actions of drug and composed of a combination of a compound (salt) having angiotensin II antagonistic action consisting of a specific benzimidazole with a compound having diuretic action or Ca antagonistic action. CONSTITUTION:This agent for the prevention or treatment of various angiotensin II-mediated diseases can be prepared by combining (A) a compound (salt) expressed by the formula [R<1> is a (substituted)hydrocarbon group; R<2> is an (esterified)carboxyl; R<3> is a group capable of forming anion or group convertible to the anion-forming group; X is a group to bond a phenylene group to a phenyl group directly or through a spacer containing <=2 atoms; Y is a bond, O, S(O)m ((m) is 0, 1 or 2) or NR<4> (R<4> is H or an alkyl) ; (n) is 1 or 2; ring A is benzene ring which may have substituent in addition to R<2>] with (B) a compound having diuretic action or a compound having calcium antagonistic action.
Inventors:
Yoshiyuki Inada
Keiji Kubo
Keiji Kubo
Application Number:
JP12483894A
Publication Date:
June 26, 2000
Filing Date:
June 07, 1994
Export Citation:
Assignee:
Takeda GmbH
International Classes:
A61K31/135; A61K31/18; A61K31/19; A61K31/192; A61K31/195; A61K31/275; A61K31/34; A61K31/341; A61K31/343; A61K31/38; A61K31/40; A61K31/402; A61K31/4035; A61K31/404; A61K31/41; A61K31/415; A61K31/4184; A61K31/42; A61K31/4245; A61K31/425; A61K31/433; A61K31/4422; A61K31/465; A61K31/495; A61K31/496; A61K31/505; A61K31/517; A61K31/519; A61K31/52; A61K31/54; A61K31/541; A61K31/549; A61K31/55; A61K31/554; A61K31/575; A61K31/585; A61K45/00; A61P7/10; A61P9/00; A61P9/04; A61P9/08; A61P9/10; A61P9/12; A61P13/02; A61P13/12; A61P15/00; A61P17/00; A61P25/20; A61P25/24; A61P25/28; A61P27/06; A61P43/00; C07D235/26; C07D235/28; C07D235/30; (IPC1-7): A61K31/4184; A61K31/192; A61K31/195; A61K31/341; A61K31/343; A61K31/402; A61K31/4035; A61K31/404; A61K31/41; A61K31/4245; A61K31/433; A61K31/4422; A61K31/495; A61K31/517; A61K31/519; A61K31/52; A61K31/549; A61K31/554; A61K45/00; A61P9/04; A61P9/10; A61P9/12; A61P13/12; A61P25/24; A61P25/28; A61P27/06
Domestic Patent References:
| JP4364171A | ||||
| JP327362A |
Attorney, Agent or Firm:
Shuichi Takahashi (2 outside)