【発明の名称】抗炎症ニトロ及びチア脂肪酸

Japanese Patent JP2003509485

A

The present invention relates to pharmaceutical compositions comprising, as an anticancer agent: (a) one or more compounds having the formula NO₂-A-B, wherein A is a saturated or unsaturated hydrocarbon chain of 14-26 double bonds, and B is (CH₂)_m(COOH)_n in which n is an integer from 0 to 2 and m is an integer from 0 to 2; or a derivative thereof in which the hydrocarbon chain has one or more than one substitution selected from the group consisting of hydroxy, hydroperoxy, epoxy and peroxy; (b) one or more compounds selected from polyunsaturated fatty acids (PUFA's) having a 16 to 26 carbon atom chain and 3 to 6 double bonds, and wherein the PUFA is covalently coupled at the carboxylic acid group to an amino acid selected from glycine and aspartic acid; (c) one or more compounds selected from unsaturated fatty acids having an 18 to 25 carbon atom chain and 1 to 6 double bonds and wherein the fatty acid has one or two beta-oxa, gamma-oxa, beta-thia, gamma-thia substitutions; or (d) one or more compounds having formula (I) wherein A' is a saturated or unsaturated hydrocarbon chain of 9-26 carbon atoms, X is oxygen or is absent and B' is (CH₂)_j(COOH)_k in which j is an integer from 1 to 3 and k is 0 or 1; or a derivative thereof in which the hydrocarbon chain has one or more than one substitution selected from the group consisting of hydroxy, hydroperoxy, epoxy and peroxy; and a pharmaceutically acceptable carrier or diluent.

Ferrante, antonio
Easton, Christopher, Jay
Shah, Lynn

JP2001524956A

March 11, 2003

September 18, 2000

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Women's and Children's Hospital
Peptec Limited

A61K8/30; A61K8/36; A61K8/40; A61K8/46; A61K31/04; A61K31/10; A61K31/19; A61K31/20; A61K31/202; A61K31/21; A61K31/335; A61P1/04; A61P1/18; A61P3/10; A61P9/00; A61P9/10; A61P11/00; A61P11/02; A61P11/06; A61P17/00; A61P17/06; A61P25/00; A61P29/00; A61P31/00; A61P33/06; A61P35/00; A61P37/02; A61P37/06; A61P37/08; A61P39/06; A61P43/00; C07C17/16; C07C45/30; C07C205/02; C07C205/03; C07C205/14; C07C205/15; C07C205/50; C07C205/51; C07C317/44; C07C321/14; C07C321/18; C07C323/52; C07C409/40; (IPC1-7): C07C205/02; A61K7/00; A61K31/04; A61K31/10; A61K31/19; A61K31/20; A61K31/202; A61P1/04; A61P1/18; A61P3/10; A61P9/00; A61P9/10; A61P11/00; A61P11/02; A61P11/06; A61P17/00; A61P17/06; A61P25/00; A61P29/00; A61P31/00; A61P33/06; A61P37/02; A61P37/06; A61P37/08; A61P39/06; A61P43/00; C07C205/03; C07C205/14; C07C205/15; C07C205/50; C07C205/51; C07C317/44; C07C321/14; C07C321/18; C07C323/52

US4780319A	1988-10-25
US3578687A	1971-05-11

Yuji Iwahashi

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