Title:
【発明の名称】抗生物質カルバペネム誘導体
Document Type and Number:
Japanese Patent JP3140058
Kind Code:
B2
Abstract:
A carbapenem compound of the formula (I) wherein: R<1> is 1-hydroxyethyl, 1-fluoroethyl or hydroxymethyl; R<2> is hydrogen or C1-4alkyl; R<3> is hydrogen or C1-4alkyl; R<4> is hydroxy or carboxy; and the phenyl ring is optionally further substituted by one or two substitutents selected from halo, cyano, C1-4alkyl, nitro, hydroxy, carboxy, C1-4alkoxy, trifluoromethyl, C1-4alkoxycarbonyl, carbamoyl, C1-4alkylcarbamoyl, di-C1-4alkylcarbamoyl, amino, C1-4alkylamino, di-C1-4alkylamino, sulphonic acid, C1-4alkylS(O)n- (wherein n is 0-2), N-C1-4alkanesulphonamido, C1-4alkanoylamino and C1-4alkanoyl(N-C1-4alkyl)amino: provided that the phenyl ring is substituted by at least one carboxy; or a pharmaceutically acceptable salt or in vivo hydrolysable ester thereof.
Inventors:
Betz, michael john
Swain, Michael Lingard
Swain, Michael Lingard
Application Number:
JP50695992A
Publication Date:
March 05, 2001
Filing Date:
April 02, 1992
Export Citation:
Assignee:
Geneca Limited
Zeneca Pharma
Zeneca Pharma
International Classes:
A61K31/397; A61K31/40; A61K31/407; A61P31/04; C07C229/56; C07D477/00; C07C229/62; C07C229/64; C07C233/54; C07D207/16; C07D403/12; C07D477/20; C07D487/04; C07F9/568; (IPC1-7): C07D487/04; A61K31/407; A61P31/04; C07D207/16; C07D403/12
Attorney, Agent or Firm:
Toshio Yano (1 outside)