Title:
【発明の名称】抗原ペプチドコンカテマー
Document Type and Number:
Japanese Patent JP2002536008
Kind Code:
A
Abstract:
Recombinant polynucleotide that contains a plurality of first polynucleotides encoding an antigenic peptide are provided by this invention. The first polynucleotides are operatively linked to each other to enhance translation of the polynucleotides to the antigenic peptide and binding of the antigenic peptide to MHC molecules. In a further embodiment, the recombinant contains a plurality of a second polynucleotide encoding multiple copies of antigenic peptides having an amino acid sequence that is different from the peptides encoded by the first polynucleotides. The polynucleotides are useful as cancer vaccines or in adoptive immunotherapy. In these embodiments, the polynucleotides encode a antigenic peptide that will induce an immune response to a tumor or cancer. Alternatively, the polypeptides encodes antigens that induce T cell anergy for use in autoimmune disorders. Still further, the antigen is a pathogenic antigen to induce an immune response against a pathogen such a virus or bacterial pathogen.
Inventors:
Shankara, Srinivas
Nicolet, Charles A.
Nicolet, Charles A.
Application Number:
JP2000598180A
Publication Date:
October 29, 2002
Filing Date:
February 10, 2000
Export Citation:
Assignee:
GENZYME CORPORATION
International Classes:
C12N15/09; A61K31/711; A61K35/76; A61K38/00; A61K38/22; A61K39/00; A61K45/06; A61K47/48; A61K48/00; A61P35/00; A61P37/02; C07K14/47; C12N5/00; C12N5/10; C12N15/19; C12N15/62; C12N15/67; (IPC1-7): C12N15/09; A61K31/711; A61K38/00; A61K38/22; A61K39/00; A61K47/48; A61K48/00; A61P35/00; A61P37/02; C12N5/00; C12N5/10
Attorney, Agent or Firm:
Kazuo Shamoto (5 outside)