Title:
【発明の名称】ペプチドライブラリー由来の抗原結合性ペプチド(アブチド)
Document Type and Number:
Japanese Patent JPH10506463
Kind Code:
A
Abstract:
Abtides are provided. Abtides are peptides identified by a two-step process of screening random peptide libraries. In the first step, the target ligand is an antibody or receptor (or derivative thereof). The peptides identified in the first screening step are used as target ligands in the second screening step. The peptides identified in the second screening step are abtides. Abtides possess binding specificities that are similar to the binding specificities of the antibodies or receptors that are used in the first screening step. Abtides may be used in place of antibodies in many assays or therapeutic applications. Abtides binding to polymorphic epithelial mucin (PEM) are provided. Also provided are methods of obtaining abtides as well as diagnostic and therapeutic compounds containing abtides.
Inventors:
Alvarez, Vernon El.
Application Number:
JP51104696A
Publication Date:
June 23, 1998
Filing Date:
September 20, 1995
Export Citation:
Assignee:
Cytogen Corporation
International Classes:
A61K38/00; A61K49/00; A61K49/04; A61K51/00; A61P35/00; C07K1/00; C07K1/04; C07K7/00; C07K14/00; G01N33/53; C07K14/47; C12N15/10; C12Q1/70; C40B30/04; C40B40/02; G01N33/68; (IPC1-7): G01N33/53; A61K38/00; A61K49/00; A61K49/04; A61K51/00; C07K1/00; C07K7/00; C12Q1/70; G01N33/53
Attorney, Agent or Firm:
Yusuke Hiraki (2 outside)
Previous Patent: 自動化された細胞学的スコアリングのために不適切な状態を検出するため...
Next Patent: 生体系における細胞異常および形態構造の診断、検出のための装置および...
Next Patent: 生体系における細胞異常および形態構造の診断、検出のための装置および...