Title:
【発明の名称】CNTFシグナル形質導入経路を用いたアッセイ系
Document Type and Number:
Japanese Patent JP3457321
Kind Code:
B2
Abstract:
The present invention provides for a stable, biologically active CNTF/receptor complex, and hybrids or mutants thereof. The invention is also based in part on the discovery that the CNTF/receptor complex promotes diferentiation through a signal transduction pathway on target cells that do not express the CNTF receptor. The invention further provides for a specific CNTFR mutant that promotes signal transduction without binding CNTF. The invention also provides for a CNTF/receptor blocking mutant, a mutant possessing a high binding affinity to CNTF, but possessing no signal transducing function. The present invention also identifies receptor components shared by the IL-6, CNTF, LIF and OSM signal transduction pathways, and the assay systems based on the use of such components.
Inventors:
Stole, nail
Janko Poros, Yogyi Day
Isle, The Ames N
Janko Poros, Yogyi Day
Isle, The Ames N
Application Number:
JP50880095A
Publication Date:
October 14, 2003
Filing Date:
September 09, 1994
Export Citation:
Assignee:
Rigieneron Pharmacy Youthicals Incorporated
Saint Youth Children's Research Hospital
Saint Youth Children's Research Hospital
International Classes:
A61K49/00; C07K14/715; C07K16/40; C12N15/09; C12P21/02; G01N33/50; G01N33/53; G01N33/566; G01N33/68; C12R1/91; (IPC1-7): G01N33/566; C12N15/09; C12P21/02; G01N33/50; G01N33/53
Attorney, Agent or Firm:
Yoshio Kawaguchi (2 outside)