Title:
【発明の名称】ベンズアゼピノン誘導体
Document Type and Number:
Japanese Patent JPH08505374
Kind Code:
A
Abstract:
PCT No. PCT/EP93/03426 Sec. 371 Date Jul. 12, 1995 Sec. 102(e) Date Jul. 12, 1995 PCT Filed Dec. 6, 1993 PCT Pub. No. WO94/13651 PCT Pub. Date Jun. 23, 1994The invention relates to substituted 3-amino-1-arylalkyl-benzazepin-2-ones of the general formula (I) wherein Ar is aryl; X is -O- or -S(O)n- and n is 0, 1 or 2; X1 is C1-C2alkylene or a direct bond; R1 is hydrogen, lower alkyl, aryl-lower alkyl or acyl; R2 is lower alkyl, hydroxy-lower alkyl, lower alkoxy-lower alkyl, aryl-lower alkoxy-lower alkyl, aryl-lower alkyl or C3-C7cycloalkyl-lower alkyl; R3 is carboxy; lower alkoxycarbonyl; lower alkoxy-lower alkoxycarbonyl; aryl-lower alkoxycarbonyl; aryloxycarbonyl; carbamoyl; carbamoyl that (i) is monosubstituted by hydroxy, lower alkanesulfonyl, halo-lower alkanesulfonyl or by arylsulfonyl, (ii) is monosubstituted or disubstituted, the substituents being independent of one another, by lower alkyl, lower alkenyl, lower alkynyl or by phenyl-lower alkyl or (iii) is disubstituted by lower alkylene or by lower alkylene-Z1-lower alkylene, Z1 being O, S or NH; 5-tetrazolyl; PO2H2; PO3H2 or SO3H2; the ring A and aromatic radicals are, independently of one another, unsubstituted or mono- or poly-substituted by substituents selected from the group consisting of: lower alkyl, aryl-lower alkyl, lower alkoxy-lower alkyl, lower alkoxy, lower alkoxy-lower alkoxy, aryl-lower alkoxy, C3-C7cycloalkyl, C3-C7cycloalkyl-lower alkyl, nitro, halogen, trifluoromethyl, amino and amino that is monosubstituted or disubstituted, the substituents being independent of one another, by lower alkyl, aryl-lower alkyl or by aryl, or disubstituted by lower alkylene or by lower alkyleneoxy-lower alkylene; or a salt thereof; to processes for the preparation thereof; and to the use thereof as well as to pharmaceutical compositions that comprise compounds of formula (I) or pharmaceutically acceptable salts thereof.
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Inventors:
Bühlmeier, Peter
Paule, Paule
Paule, Paule
Application Number:
JP51376094A
Publication Date:
June 11, 1996
Filing Date:
December 06, 1993
Export Citation:
Assignee:
Ciba-Geigy Akchen Gezel Shaft
International Classes:
A61K31/55; A61K31/554; A61P9/00; A61P13/02; A61P15/00; A61P25/00; A61P25/08; A61P25/28; A61P43/00; C07D267/14; C07D281/10; (IPC1-7): C07D267/14; A61K31/55; C07D281/10
Attorney, Agent or Firm:
Takashi Ishida (3 others)