Title:
【発明の名称】ベンゾピランおよびベンゾ縮合した化合物、それらの製造方法ならびにロイコトリエンB▲下4▼(LTB▲下4▼)アンタゴニストとしてのそれらの使用
Document Type and Number:
Japanese Patent JP2983295
Kind Code:
B2
Abstract:
This invention relates to novel benzopyran and other benzo-fused leukotriene B4 (LTB4) antagonists and the pharmaceutically acceptable salts thereof, to pharmaceutical compositions containing such compounds or a pharmaceutically acceptable salt thereof, and to methods of using such compounds as LTB4 antagonists. The compounds and the pharmaceutically acceptable salts of this invention inhibit the action of LTB4 and are therefore useful in the treatment of LTB4 induced illnesses such as inflammatory disorders including rheumatoid arthritis, osteoarthritis, inflammatory bowel disease, psoriasis and other skin disorders such as eczema, erythema, pruritus and acne, stroke and other forms of reperfusion injury, graft rejection, autoimmune diseases, asthma, and other conditions where marked neutrophil infiltration occurs.
Inventors:
DOMUBUROSUKI MAAKU EI
KOTSUKU KEUIN
PISUKOPIO ANSONII DANIERU
KOTSUKU KEUIN
PISUKOPIO ANSONII DANIERU
Application Number:
JP51305796A
Publication Date:
November 29, 1999
Filing Date:
May 26, 1995
Export Citation:
Assignee:
FUAIZAA INC
International Classes:
A61K31/00; A61K31/35; A61K31/352; A61K31/353; A61P11/00; A61P11/06; A61P29/00; A61P37/00; A61P37/06; C07C35/23; C07C35/52; C07C39/14; C07C39/17; C07D263/14; C07C39/38; C07C65/17; C07C65/26; C07C65/36; C07D311/04; C07D311/22; C07D311/24; C07D311/48; C07D311/58; C07D413/04; (IPC1-7): C07C35/23; C07C35/52; C07C39/17; C07C39/38; C07C65/17; C07C65/26; C07C65/36; C07D311/24; C07D311/58
Other References:
【文献】国際公開93/15067(WO,A1)
【文献】国際公開93/15066(WO,A1)
【文献】国際公開93/15066(WO,A1)
Attorney, Agent or Firm:
Kazuo Shamoto (4 outside)