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Title:
【発明の名称】二環式フィブリノーゲン拮抗薬
Document Type and Number:
Japanese Patent JP3497164
Kind Code:
B2
Abstract:
PCT No. PCT/US92/05463 Sec. 371 Date Jun. 26, 1992 Sec. 102(e) Date Jun. 26, 1992 PCT Filed Jun. 26, 1992 PCT Pub. No. WO93/00095 PCT Pub. Date Jan. 7, 1993This invention relates to compounds of the formula: wherein A1 to A5 form an accessible substituted seven-membered ring, which may be saturated or unsaturated, optionally containing up to two heteroatoms chosen from the group of O, S and N wherein S and N may be optionally oxidized; D1 to D4 form an accessible substituted six membered ring, optionally containing up to two nitrogen atoms; R is at least one substituent chosen from the group of R7, or Q-C1-4alkyl, Q-C2-4alkenyl, Q-C2-4alkynyl, preferably substituted by an acidic function; R* is H, Q-C1-6alkyl, Q-C1-6oxoalkyl, Q-C2-6alkenyl or Q-C2-4alkynyl, C3-6cycloalkyl, Ar or Het, optionally substituted by one or more substitutents; and R6 is preferably a substituent containing a basic nitrogen moiety; or a pharmaceutically acceptable salt thereof, which are effective for inhibiting platelet aggregation, pharmaceutical compositions for effecting such activity, and a method for inhibiting platelet aggregation.

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Inventors:
Bondel, William Edward
Kohran, James Francis
Huffman, William Francis
Keenan, Richard McRoch
Kuu, Thomas Wen-Hu
Kenland Alan, Newlander
Application Number:
JP50170293A
Publication Date:
February 16, 2004
Filing Date:
June 26, 1992
Export Citation:
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Assignee:
SMITHKLINE BEECHAM CORPORATION
International Classes:
A61K31/551; A61K31/5513; A61K31/675; A61K31/69; A61P7/02; A61P9/08; A61P9/10; C07D223/16; C07D243/12; C07D243/14; A61K31/55; C07D267/14; C07D281/10; C07D471/04; C07D491/048; C07F9/40; (IPC1-7): C07D223/16; A61K31/5513; A61P7/02; A61P9/10; C07D243/12; C07D243/14; C07D267/14; C07D471/04; C07D491/048; C07F9/40
Attorney, Agent or Firm:
Aoyama Ryo (1 person outside)



 
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