Title:
【発明の名称】カルボン酸及びヒドロキサム酸メタロプロテアーゼ-阻害剤化合物、それらの製造方法及びそれらを含む製薬学的組成物
Document Type and Number:
Japanese Patent JP2002519342
Kind Code:
A
Abstract:
The invention concerns a compound of formula (I) wherein: n is equal to 0 or 1; R1, R2, R3, R4 represent a hydrogen or an alkyl group, or R1 and R3 together form a cycloalkyl group; R5 represents a hydrogen, an alkyl, cycloalkyl, cycloalkylalkyl, aryl, arylalkyl, heteroaryl, hetereoalkylalkyl, hetereocycloalkyl, hetereocycloalkylalkyl group (all optionally substituted), or a -CO-R6 group; and R6 represents R7 or OR7 or NR7R8, with R7 representing an aryl, arylalkyl, heteroaryl or heteroarylalkyl, heterocycloalkyl, heterocycloalkylalkyl group (all optionally substituted), and R8 representing an alkyl, aryl, arylalkyl, heteroaryl or heteroarylalkyl (all optionally substituted); or R5 and R6 form with the nitrogen atom and the Z group bearing them a saturated monocyclic, bicyclic or tricyclic group, partially unsaturated or unsaturated, with 5 to 16 chain links containing 1 to 7 heteroatoms and optionally substituted; R10 represents a hydrogen atom or a hydroxy group, and in the latter case R1, R2, R3, R4 are independently selected among hydrogen and alkyl; Z represents a hydroxy, alkoxy, alkenyloxy, benzyloxy group or a NH-OR group; X represents a sulphur, a SO, SO2 group (in those cases where R3 and R4 are different from an alkyl) or a group -CO-O- (in which case R1 and R3 form a cycloalkyl group), or X represents an oxygen atom; W represents a W1-(A)p or W1-B-W2-(A)p group wherein W1 and W2 represent an aryl or heteroaryl group, A is a standard substituent of aromatic cycles, B a bond, an oxygen or an alkylene, alkenylene, alkynylene group, and p is an integer ranging between 0 and 5; T1 and T2 represent a bond or an alkylene, alkenylene, or alkynylene group. The invention is useful for preparing medicines.
Inventors:
Kasara, Patrick
Cholet, Anne-Marie
Rudigaler, Thierry
Atasi, Gurham
Bonne, Jacqueline
Alain Pierre
Sabatini, massimo
Tuke, Gordon
Gilbo, Nicola
Cholet, Anne-Marie
Rudigaler, Thierry
Atasi, Gurham
Bonne, Jacqueline
Alain Pierre
Sabatini, massimo
Tuke, Gordon
Gilbo, Nicola
Application Number:
JP2000557234A
Publication Date:
July 02, 2002
Filing Date:
June 29, 1999
Export Citation:
Assignee:
Réra Bora Toir Servier
International Classes:
A61K31/18; A61K31/197; A61K31/403; A61K31/4035; A61K31/425; A61K31/426; A61K31/428; A61K31/517; A61K31/53; A61K31/535; A61K31/536; A61K31/537; A61P19/02; A61P29/00; A61P35/00; A61P35/04; A61P43/00; C07C233/82; C07C233/83; C07C259/10; C07C311/29; C07D209/48; C07D209/66; C07D231/22; C07D233/72; C07D233/74; C07D237/32; C07D239/96; C07D253/08; C07D265/06; C07D253/04; C07D265/16; C07D275/04; C07D275/06; C07D277/20; C07D277/34; C07D401/12; C07D403/12; C07D409/12; C07D471/04; (IPC1-7): C07C233/83; A61K31/18; A61K31/197; A61K31/403; A61K31/4035; A61K31/425; A61K31/428; A61K31/517; A61K31/53; A61K31/535; A61K31/536; A61P19/02; A61P29/00; A61P35/00; A61P43/00; C07C311/29; C07D209/48; C07D209/66; C07D237/32; C07D239/96; C07D253/04; C07D253/08; C07D265/06; C07D265/16; C07D275/04; C07D277/34; C07D401/12; C07D403/12; C07D409/12; C07D471/04
Attorney, Agent or Firm:
Hajime Tsukuni (1 person outside)